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Aminohexylgeldanamycin hydrochloride

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Catalog No. T38522Cas No. 1146534-45-3
Alias Aminohexylgeldanamycin hydrochloride, AHGDM hydrochloride

Aminohexylgeldanamycin (AHGDM) hydrochloride is a Geldanamycin derivative and a powerful inhibitor of HSP90. It exhibits significant antiangiogenic and antitumor properties.

Aminohexylgeldanamycin hydrochloride
Other Forms of Aminohexylgeldanamycin hydrochloride:
AminohexylgeldanamycinT37377485395-71-9
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Aminohexylgeldanamycin hydrochloride

😃Good
Catalog No. T38522Alias Aminohexylgeldanamycin hydrochloride, AHGDM hydrochlorideCas No. 1146534-45-3
Aminohexylgeldanamycin (AHGDM) hydrochloride is a Geldanamycin derivative and a powerful inhibitor of HSP90. It exhibits significant antiangiogenic and antitumor properties.
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Product Introduction

Bioactivity
Description
Aminohexylgeldanamycin (AHGDM) hydrochloride is a Geldanamycin derivative and a powerful inhibitor of HSP90. It exhibits significant antiangiogenic and antitumor properties.
In vitro
HPMA copolymer-aminohexylgeldanamycin conjugates target cell surface-expressed GRP78 in prostate cancer.
SynonymsAminohexylgeldanamycin hydrochloride, AHGDM hydrochloride
Chemical Properties
Molecular Weight681.27
FormulaC34H53ClN4O8
Cas No.1146534-45-3
SmilesCl.CO[C@H]1C[C@H](C)CC2=C(NCCCCCCN)C(=O)C=C(NC(=O)\C(C)=C/C=C/[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1O)C2=O |c:7,25,t:19,27,38|
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

Aminohexylgeldanamycin HydrochlorideAHGDM HydrochlorideADCCytotoxinADC Cytotoxin
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