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NEO-201
(Synonyms: NEO201) Copy Product Info
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Synonyms: NEO201
Catalog No. T9901A-058 Copy Product Info
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NEO-201 is a humanized antibody targeting CEACAM6/CD66c with antitumor activity that binds to tumor-associated variants of carcinoembryonic antigen-associated cellular adhesion molecule (CEACAM)-5 and CEACAM-6, and can be used in the study of breast cancer.
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $98 | - | In Stock | |
| 5 mg | $250 | - | In Stock | |
| 10 mg | $363 | - | In Stock | |
| 25 mg | $586 | - | In Stock | |
| 50 mg | Preferential | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:99.1% (SDS-PAGE); 96.6% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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| Description | NEO-201 is a humanized antibody targeting CEACAM6/CD66c with antitumor activity that binds to tumor-associated variants of carcinoembryonic antigen-associated cellular adhesion molecule (CEACAM)-5 and CEACAM-6, and can be used in the study of breast cancer. |
| In vitro | Methods: Tumor target cells were labeled with Calcein AM, treated with 10 μg/mL NEO-201, and co-incubated with NK-92 cells at a target-to-killer cell ratio of 1.56:1 to 12.5:1 for 16 hours; the number of live cells was detected using Celigo imaging, and the NK cell-specific killing rate was calculated. Results: NEO-201 significantly enhanced the killing activity of NK-92 cells against CEACAM5⁺/NEO-201⁺ tumor cells. The killing effect was positively correlated with the expression level of CEACAM5⁺/NEO-201⁺ and was not affected by the expression level of CEACAM6 in tumor cells. [1] |
| In vivo | Methods: Ovarian carcinoma in situ models (intra-ovarian injection of OV90) and peritoneal metastasis models were established. NEO-201 (250 μg/mouse) was administered via intraperitoneal injection on days 1, 4, and 8. Tumor volume was monitored by ultrasound, and mouse survival was recorded. Results: NEO-201 prolonged the survival of tumor-bearing mice. |
| Synonyms | NEO201 |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | CEACAM6/CD66c |
| Molecular Weight | 145.58 kDa |
| Isotype | Human IgG1 kappa |
| Recommended Isotype Control |
| Storage | Store at low temperature -20°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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Related Tags: NEO-201 chemical structure | NEO-201 in vivo | NEO-201 in vitro | NEO-201 molecular weight
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