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DKFZ-748

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Catalog No. T73387Cas No. 2490709-68-5
Alias DKFZ748

DKFZ-748 is a selective HDAC10 inhibitor and has a dose-dependent growth inhibitory effect on HeLa cells.

DKFZ-748

DKFZ-748

🥰Excellent
Catalog No. T73387Alias DKFZ748Cas No. 2490709-68-5
DKFZ-748 is a selective HDAC10 inhibitor and has a dose-dependent growth inhibitory effect on HeLa cells.
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1 mg$98In Stock
5 mg$243In Stock
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Product Introduction

Bioactivity
Description
DKFZ-748 is a selective HDAC10 inhibitor and has a dose-dependent growth inhibitory effect on HeLa cells.
In vitro
DKFZ-748 inhibits HeLa cell growth in a dose-dependent manner and induces HDAC acetylation in BE(2)-C cells (1–100 μM, 72 h), with significant effects observed only at the highest concentration (100 μM). DKFZ-748 also causes dose-dependent accumulation of N8-acetyl- and N1,8-diacetylspermidine[1].
AliasDKFZ748
Chemical Properties
Molecular Weight329.39
FormulaC18H23N3O3
Cas No.2490709-68-5
SmilesO=C(NCCN(C)CCCC(=O)NO)C1=CC=CC=2C=CC=CC21
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (242.87 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.0359 mL15.1796 mL30.3591 mL151.7957 mL
5 mM0.6072 mL3.0359 mL6.0718 mL30.3591 mL
10 mM0.3036 mL1.5180 mL3.0359 mL15.1796 mL
20 mM0.1518 mL0.7590 mL1.5180 mL7.5898 mL
50 mM0.0607 mL0.3036 mL0.6072 mL3.0359 mL
100 mM0.0304 mL0.1518 mL0.3036 mL1.5180 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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