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DKFZ-748
🥰Excellent
Catalog No. T73387Cas No. 2490709-68-5
Alias DKFZ748
DKFZ-748 is a selective HDAC10 inhibitor and has a dose-dependent growth inhibitory effect on HeLa cells.
DKFZ-748
🥰Excellent
Catalog No. T73387Alias DKFZ748Cas No. 2490709-68-5
DKFZ-748 is a selective HDAC10 inhibitor and has a dose-dependent growth inhibitory effect on HeLa cells.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $98 | In Stock | |
| 5 mg | $243 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | DKFZ-748 is a selective HDAC10 inhibitor and has a dose-dependent growth inhibitory effect on HeLa cells. |
| In vitro | DKFZ-748 inhibits HeLa cell growth in a dose-dependent manner and induces HDAC acetylation in BE(2)-C cells (1–100 μM, 72 h), with significant effects observed only at the highest concentration (100 μM). DKFZ-748 also causes dose-dependent accumulation of N8-acetyl- and N1,8-diacetylspermidine[1]. |
| Alias | DKFZ748 |
| Molecular Weight | 329.39 |
| Formula | C18H23N3O3 |
| Cas No. | 2490709-68-5 |
| Smiles | O=C(NCCN(C)CCCC(=O)NO)C1=CC=CC=2C=CC=CC21 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (242.87 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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