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DKFZ-748

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Catalog No. T73387Cas No. 2490709-68-5
Alias DKFZ748

DKFZ-748 is a selective HDAC10 inhibitor and has a dose-dependent growth inhibitory effect on HeLa cells.

DKFZ-748

DKFZ-748

😃Good
Purity: 98.10%
Catalog No. T73387Alias DKFZ748Cas No. 2490709-68-5
DKFZ-748 is a selective HDAC10 inhibitor and has a dose-dependent growth inhibitory effect on HeLa cells.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$84In StockIn Stock
5 mg$198In StockIn Stock
10 mg$328In StockIn Stock
25 mg$593In StockIn Stock
50 mg$865In StockIn Stock
100 mg$1,190-In Stock
200 mg$1,580-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98.10%
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Product Introduction

Bioactivity
Description
DKFZ-748 is a selective HDAC10 inhibitor and has a dose-dependent growth inhibitory effect on HeLa cells.
In vitro
DKFZ-748 inhibits HeLa cell growth in a dose-dependent manner and induces HDAC acetylation in BE(2)-C cells (1–100 μM, 72 h), with significant effects observed only at the highest concentration (100 μM). DKFZ-748 also causes dose-dependent accumulation of N8-acetyl- and N1,8-diacetylspermidine[1].
SynonymsDKFZ748
Chemical Properties
Molecular Weight329.39
FormulaC18H23N3O3
Cas No.2490709-68-5
SmilesO=C(NCCN(C)CCCC(=O)NO)C1=CC=CC=2C=CC=CC21
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (242.87 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (10.02 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.0359 mL15.1796 mL30.3591 mL151.7957 mL
5 mM0.6072 mL3.0359 mL6.0718 mL30.3591 mL
10 mM0.3036 mL1.5180 mL3.0359 mL15.1796 mL
20 mM0.1518 mL0.7590 mL1.5180 mL7.5898 mL
50 mM0.0607 mL0.3036 mL0.6072 mL3.0359 mL
100 mM0.0304 mL0.1518 mL0.3036 mL1.5180 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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