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Biotin alkyne

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Catalog No. T66674Cas No. 773888-45-2

Biotin alkyne is a PEG-based PROTAC linker for PROTAC synthesis, whose alkyne group undergoes click chemistry reactions with azide-containing molecules.

Biotin alkyne

Biotin alkyne

😃Good
Purity: 99.667%
Catalog No. T66674Cas No. 773888-45-2
Biotin alkyne is a PEG-based PROTAC linker for PROTAC synthesis, whose alkyne group undergoes click chemistry reactions with azide-containing molecules.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 mg$34-In Stock
50 mg$47-In Stock
100 mg$68-In Stock
500 mg$162-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Purity:99.667%
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COA LCMS HNMR

Product Introduction

Bioactivity
Description
Biotin alkyne is a PEG-based PROTAC linker for PROTAC synthesis, whose alkyne group undergoes click chemistry reactions with azide-containing molecules.
Chemical Properties
Molecular Weight281.37
FormulaC13H19N3O2S
Cas No.773888-45-2
SmilesC#CCNC(=O)CCCC[C@H]1[C@]2([H])[C@@](CS1)([H])NC(=O)N2
ColorWhite
AppearanceSolid
Storage & Solubility Information
Storagestore at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 200 mg/mL (710.81 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (17.77 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.5540 mL17.7702 mL35.5404 mL177.7020 mL
5 mM0.7108 mL3.5540 mL7.1081 mL35.5404 mL
10 mM0.3554 mL1.7770 mL3.5540 mL17.7702 mL
20 mM0.1777 mL0.8885 mL1.7770 mL8.8851 mL
50 mM0.0711 mL0.3554 mL0.7108 mL3.5540 mL
100 mM0.0355 mL0.1777 mL0.3554 mL1.7770 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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