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Pedaliin

Name: Pedaliin
Brand: TargetMol
SKU: TN5546
Rating: 4.5 (1 reviews)

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Catalog No. TN5546Cas No. 22860-72-6

Alias Pedalitin 6-O-glucoside, Pedalin, Glucosyl-6-pedalitin

Pedaliin is a flavonoid extracted from the above-ground parts of sesame (Sesamum indicum L) and the Tibetan medicine Dracocephalum tanguticum Maxim.Pedaliin has shown antioxidant and anticancer effects against colon cancer in vitro, and can be used in the study of cardiovascular diseases.

Pedaliin

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Purity: 99.96%

Catalog No. TN5546Alias Pedalitin 6-O-glucoside, Pedalin, Glucosyl-6-pedalitinCas No. 22860-72-6

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 mg	$998	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$1,250	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.96%

Appearance:Solid

Color:White

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COA CNMR HNMR HPLC MS

Product Introduction

Bioactivity

Description	Pedaliin is a flavonoid extracted from the above-ground parts of sesame (Sesamum indicum L) and the Tibetan medicine Dracocephalum tanguticum Maxim.Pedaliin has shown antioxidant and anticancer effects against colon cancer in vitro, and can be used in the study of cardiovascular diseases.
Targets&IC50	BSA glycation:41.8 μM
In vitro	Pedaliin dose-dependently attenuates the growth of human colon cancer cells, HT29 and HCT116, with concentrations ranging from 0 to 35 μM after 72 hours of treatment[2]. With a concentration range of 3.5-35 μM, a 30-minute incubation at 37 ℃, Pedaliin exhibits ferric reducing antioxidant power (FRAP)[1]. Under non-cytotoxic conditions, Pedaliin at 7 μM for 48 hours alleviates the invasion and migration of HT29 and HCT116 cells[1]. Additionally, Pedaliin, at a volume of 20 μL, demonstrates high 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, oxygen radical absorbance capacity (ORAC), and in vitro antiglycation activities. It also inhibits BSA glycation with an IC50 value of 41.8 μM[1].
Synonyms	Pedalitin 6-O-glucoside, Pedalin, Glucosyl-6-pedalitin

Chemical Properties

Molecular Weight	478.4
Formula	C₂₂H₂₂O₁₂
Cas No.	22860-72-6
Smiles	OC1=C2C(OC(=CC2=O)C3=CC(O)=C(O)C=C3)=CC(OC)=C1O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O
Relative Density.	1.674 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc