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SF1126

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Catalog No. T16875Cas No. 936487-67-1

SF1126 is a relevant pan and dual first-in-class PI3K/BRD4 inhibitor. An RGDS-conjugated LY294002 prodrug, it is designed for increased solubility and specifically binds to integrins within the tumor compartment.

SF1126

SF1126

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Catalog No. T16875Cas No. 936487-67-1
SF1126 is a relevant pan and dual first-in-class PI3K/BRD4 inhibitor. An RGDS-conjugated LY294002 prodrug, it is designed for increased solubility and specifically binds to integrins within the tumor compartment.
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25 mg$1,520InquiryInquiry
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Product Introduction

Bioactivity
Description
SF1126 is a relevant pan and dual first-in-class PI3K/BRD4 inhibitor. An RGDS-conjugated LY294002 prodrug, it is designed for increased solubility and specifically binds to integrins within the tumor compartment.
In vitro
SF1126 (0.5-2.5 μM; pre-30 minutes) and sorafenib shows that combined treatment of SF1126 and sorafenib blocks multiple key enzymes in PI3K/AKT/mTOR and Ras/Raf/MAPK pathway. SF1126 (1-10 μM; 24 hours) causes cell-cycle arrest with a proportional increase in G0-G1 and a decrease in the number of cells in the S-phase in Hep 3B, Hep G2, SK-Hep1, and Huh7 cells. SF1126 (0-6 μM; 48 hours) inhibits Hep3B, HepG2, SK-Hep1, and Huh7 cell proliferation with IC50s of 5.05, 6.89, 3.14, and 2.14 μM, respectively [1].
Chemical Properties
Molecular Weight852.84
FormulaC39H48N8O14
Cas No.936487-67-1
SmilesC(OC(CCC(N[C@H](C(NCC(N[C@H](C(N[C@H](C(O)=O)CO)=O)CC([O-])=O)=O)=O)CCCNC(=N)N)=O)=O)[N+]1(CCOCC1)C=2OC3=C(C=CC=C3C(=O)C2)C4=CC=CC=C4
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

SF-1126SF1126SF 1126PI3K/BRD4
Related Tags: buy SF1126 | purchase SF1126 | SF1126 cost | order SF1126 | SF1126 chemical structure | SF1126 in vitro | SF1126 formula | SF1126 molecular weight
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