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Description | Mal-PEG8-Boc, a PEG-based linker for PROTACs, connects two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells. |
In vitro | PROTACs consist of two distinct ligands joined by a linker: one targets an E3 ubiquitin ligase, while the other binds to the target protein. These compounds harness the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
Molecular Weight | 577.66 |
Formula | C27H47NO12 |
Cas No. | 2055048-43-4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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