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Falcarindiol
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Catalog No. T72961Cas No. 55297-87-5
Falcarindiol is an orally active natural polyacetylene compound exhibiting anti-inflammatory and antiproliferative properties. It inhibits NO production in LPS-induced mouse macrophages, reduces tyrosine phosphorylation of JAK1 and JAK2, and modulates STAT1 nuclear translocation, thereby suppressing iNOS expression.
Falcarindiol
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Purity: 99.38%
Catalog No. T72961Cas No. 55297-87-5
Falcarindiol is an orally active natural polyacetylene compound exhibiting anti-inflammatory and antiproliferative properties. It inhibits NO production in LPS-induced mouse macrophages, reduces tyrosine phosphorylation of JAK1 and JAK2, and modulates STAT1 nuclear translocation, thereby suppressing iNOS expression.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $168 | - | In Stock | |
| 5 mg | $416 | - | In Stock | |
| 10 mg | $618 | - | In Stock | |
| 25 mg | $985 | - | In Stock | |
| 50 mg | $1,280 | - | In Stock | |
| 100 mg | $1,930 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.38%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Falcarindiol is an orally active natural polyacetylene compound exhibiting anti-inflammatory and antiproliferative properties. It inhibits NO production in LPS-induced mouse macrophages, reduces tyrosine phosphorylation of JAK1 and JAK2, and modulates STAT1 nuclear translocation, thereby suppressing iNOS expression. |
| In vitro | Falcarindiol (1-20 μM) exhibited low toxicity towards hMSCs and HT-29 cells, while demonstrating cytotoxicity at concentrations above 50 μM [2]. After 24 hours of treatment with Falcarindiol (5 μM), the expression of the PPARγ2 gene in HT-29 cells was significantly upregulated [2]. |
| In vivo | Falcarindiol (7 μg/g, diet) significantly upregulates the gene expression of cholesterol transporter (ABCA1) in colorectal tumor tissues of 5-week-old male F344 strain rats [2]. |
| Molecular Weight | 260.37 |
| Formula | C17H24O2 |
| Cas No. | 55297-87-5 |
| Smiles | C([C@H](/C=C\CCCCCCC)O)#CC#C[C@H](C=C)O |
| Color | Transparent |
| Appearance | Liquid |
Storage & Solubility Information
| Storage | keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO: ≥ 25 mg/mL, Sonication is recommended. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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