Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DDO-2093, a powerful inhibitor of the MLL1-WDR5 protein-protein interaction (IC50 = 8.6 nM; Kd = 11.6 nM), exhibits prominent antitumor effects. Notably, DDO-2093 selectively hampers the catalytic activity of the MLL complex.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | Inquiry | $ 970.00 |
Description | DDO-2093, a powerful inhibitor of the MLL1-WDR5 protein-protein interaction (IC50 = 8.6 nM; Kd = 11.6 nM), exhibits prominent antitumor effects. Notably, DDO-2093 selectively hampers the catalytic activity of the MLL complex. |
In vitro | DDO-2093 (5 μM; pretreated 7 days) suppresses the expression of MLL-fusion protein dependent genes (HOXA9 and Meis1)[1]. Utilizing Western Blot Analysis[1] on MV4-11 cells at concentrations of 1, 2.5, 5, and 10 μM with a 7-day pretreatment, the results demonstrate a dose-dependent decrease in the mono-, di-, and trimethylation of H3K4. |
In vivo | DDO-2093, administered intraperitoneally (i.p.) at doses ranging from 20 mg/kg to 80 mg/kg every other day for a duration of 21 days, significantly reduced both the size and weight of tumors in a dose-dependent manner in female nude mice bearing MV4-11 human leukemia cancer xenografts. Specifically, tumor volume growth inhibition (GI) values were observed to increase with higher doses, measuring 13.7% for 20 mg/kg, 37.6% for 40 mg/kg, and 63.9% for 80 mg/kg, respectively. |
Molecular Weight | 614.12 |
Formula | C29H37ClFN9O3 |
CAS No. | 2250024-74-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
DDO-2093 2250024-74-7 DDO2093 DDO 2093 inhibitor inhibit