Shopping Cart

Your shopping cart is currently empty

MM 11253

Name: MM 11253
Brand: TargetMol
SKU: T23005
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T23005Cas No. 345952-44-5

Alias MM-11253

MM 11253 is a RARγ antagonist with IC50 of 44nM.

MM 11253

Copy Product Info

😃Good

Purity: 99.41%

Catalog No. T23005Alias MM-11253Cas No. 345952-44-5

MM 11253 is a RARγ antagonist with IC50 of 44nM.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$34	In Stock	In Stock
5 mg	$80	In Stock	In Stock
10 mg	$128	In Stock	In Stock
25 mg	$289	In Stock	In Stock
50 mg	$455	In Stock	In Stock
100 mg	$672	-	In Stock
1 mL x 10 mM (in DMSO)	$82	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.41%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	MM 11253 is a RARγ antagonist with IC50 of 44nM.
Targets&IC50	RARγ:44 nM (IC50), RARβ:>1000 nM (IC50), RXRα:>1000 nM (IC50), RARα:1000 nM (IC50)
In vitro	MM11253 inhibits the action of both MM11254 and MM11389, which typically prevent the growth of squamous cell carcinoma cells, as documented in source [2].
Synonyms	MM-11253

Chemical Properties

Molecular Weight	462.67
Formula	C₂₈H₃₀O₂S₂
Cas No.	345952-44-5
Smiles	CC1(C)CCC(C)(C)c2cc(ccc12)C1(SCCS1)c1ccc2cc(ccc2c1)C(O)=O
Relative Density.	1.202 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 150 mg/mL (324.21 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1614 mL	10.8068 mL	21.6137 mL	108.0684 mL
5 mM	0.4323 mL	2.1614 mL	4.3227 mL	21.6137 mL
10 mM	0.2161 mL	1.0807 mL	2.1614 mL	10.8068 mL
20 mM	0.1081 mL	0.5403 mL	1.0807 mL	5.4034 mL
50 mM	0.0432 mL	0.2161 mL	0.4323 mL	2.1614 mL
100 mM	0.0216 mL	0.1081 mL	0.2161 mL	1.0807 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc