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Isosaponarin

Name: Isosaponarin
Brand: TargetMol
SKU: T4430
Price: 280 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4430Cas No. 19416-87-6

Isosaponarin is a natural product with multiple activities. It inhibits the increase in Ca2+ levels induced by 4-aminopyridine in rat synaptosomes without affecting the membrane potential of synaptosomes, while reducing the phosphorylation of PKC, PKCα, SNAP-25, and MARCKS, thereby inhibiting the release of glutamate from vesicles in synaptosomes.

Isosaponarin

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Purity: 99.12%

Catalog No. T4430Cas No. 19416-87-6

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$280	-	In Stock
5 mg	$789	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.12%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Isosaponarin is a natural product with multiple activities. It inhibits the increase in Ca2+ levels induced by 4-aminopyridine in rat synaptosomes without affecting the membrane potential of synaptosomes, while reducing the phosphorylation of PKC, PKCα, SNAP-25, and MARCKS, thereby inhibiting the release of glutamate from vesicles in synaptosomes.
In vitro	Methods: Human fibroblasts were treated with Isosaponarin at concentrations of 0.001–0.1 μg/mL for 24 hours to evaluate its effects on collagen synthesis and the expression of related proteins. Results: Isosaponarin promoted collagen synthesis, which was closely associated with the upregulation of TβR-II and P4H production. [1]
In vivo	Methods: A single oral dose of 50 mg/kg Isosaponarin was administered to 6-week-old female ICR mice to investigate its intestinal metabolism as well as absorption and excretion in the body. Results: Isosaponarin was metabolized to Isovitexin in the intestine, and most of it was not absorbed but excreted via feces. [2]

Chemical Properties

Molecular Weight	594.52
Formula	C₂₇H₃₀O₁₅
Cas No.	19416-87-6
Smiles	OC1=C2C(OC(=CC2=O)C3=CC=C(O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)C=C3)=CC(O)=C1[C@@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O
Relative Density.	1.723g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (168.2 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6820 mL	8.4101 mL	16.8203 mL	84.1015 mL
5 mM	0.3364 mL	1.6820 mL	3.3641 mL	16.8203 mL
10 mM	0.1682 mL	0.8410 mL	1.6820 mL	8.4101 mL
20 mM	0.0841 mL	0.4205 mL	0.8410 mL	4.2051 mL
50 mM	0.0336 mL	0.1682 mL	0.3364 mL	1.6820 mL
100 mM	0.0168 mL	0.0841 mL	0.1682 mL	0.8410 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc