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Isosaponarin is a natural product with multiple activities. It inhibits the increase in Ca2+ levels induced by 4-aminopyridine in rat synaptosomes without affecting the membrane potential of synaptosomes, while reducing the phosphorylation of PKC, PKCα, SNAP-25, and MARCKS, thereby inhibiting the release of glutamate from vesicles in synaptosomes.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $280 | In Stock | |
5 mg | $789 | In Stock |
Description | Isosaponarin is a natural product with multiple activities. It inhibits the increase in Ca2+ levels induced by 4-aminopyridine in rat synaptosomes without affecting the membrane potential of synaptosomes, while reducing the phosphorylation of PKC, PKCα, SNAP-25, and MARCKS, thereby inhibiting the release of glutamate from vesicles in synaptosomes. |
In vitro | Methods: Human fibroblasts were treated with Isosaponarin at concentrations of 0.001–0.1 μg/mL for 24 hours to evaluate its effects on collagen synthesis and the expression of related proteins. Results: Isosaponarin promoted collagen synthesis, which was closely associated with the upregulation of TβR-II and P4H production. [1] |
In vivo | Methods: A single oral dose of 50 mg/kg Isosaponarin was administered to 6-week-old female ICR mice to investigate its intestinal metabolism as well as absorption and excretion in the body. Results: Isosaponarin was metabolized to Isovitexin in the intestine, and most of it was not absorbed but excreted via feces. [2] |
Molecular Weight | 594.52 |
Formula | C27H30O15 |
Cas No. | 19416-87-6 |
Smiles | OC1=C2C(OC(=CC2=O)C3=CC=C(O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)C=C3)=CC(O)=C1[C@@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O |
Relative Density. | 1.723g/cm3 |
Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 100 mg/mL (168.2 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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