Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BET-IN-15 (compound 1) is a potent, orally active inhibitor of BET, demonstrating inhibitory IC50 values of 0.64 nM for BRD4-BD1 and 0.25 nM for BRD4-BD2. It exhibits antiproliferative activity [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | BET-IN-15 (compound 1) is a potent, orally active inhibitor of BET, demonstrating inhibitory IC50 values of 0.64 nM for BRD4-BD1 and 0.25 nM for BRD4-BD2. It exhibits antiproliferative activity [1]. |
Targets&IC50 | BRD4 BD1:0.64 nM, BRD4 BD2:0.25 nM |
In vitro | BET-IN-15 (Compound 1) demonstrated antiproliferative activity over 72 hours, with IC50 values of 3.14 nM and 1.56 nM against MV4-11 and Kasumi-1 cells, respectively [1]. |
In vivo | Compound 1 (BET-IN-15), upon 72-hour exposure, exhibits antiproliferative activity with IC50s of 3.14 nM and 1.56 nM against MV4-11 and Kasumi-1 cells, respectively [1]. |
Molecular Weight | 444.45 |
Formula | C21H18F2N4O3S |
CAS No. | 2408994-22-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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BET-IN-15 2408994-22-7 Chromatin/Epigenetic Epigenetic Reader Domain inhibitor inhibit