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Sulfo-NHS-Acetate (Synonyms: Sulfosuccinimidyl acetate)

Name: Sulfo-NHS-Acetate
Brand: TargetMol
SKU: T16959
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T16959 Copy Product Info

Purity: 98.33%

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Sulfo-NHS-Acetate (Sulfosuccinimidyl acetate) is a PROTAC linker belonging to the alkyl chain class, useful for synthesizing PROTAC molecules.

Sulfo-NHS-Acetate

Copy Product Info

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Catalog No. T16959

Synonyms Sulfosuccinimidyl acetate

Sulfo-NHS-Acetate (Sulfosuccinimidyl acetate) is a PROTAC linker belonging to the alkyl chain class, useful for synthesizing PROTAC molecules.

Cas No. 152305-87-8

Pack Size	Price	USA Stock	Global Stock	Quantity
10 mg	$35	In Stock	In Stock
25 mg	$54	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:98.33%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Sulfo-NHS-Acetate (Sulfosuccinimidyl acetate) is a PROTAC linker belonging to the alkyl chain class, useful for synthesizing PROTAC molecules.
In vitro	PROTACs (Proteolysis-Targeting Chimeras) consist of two ligands joined by a linker: one binding an E3 ubiquitin ligase and the other targeting the specific protein. They utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
Synonyms	Sulfosuccinimidyl acetate

Chemical Properties

Molecular Weight	237.19
Formula	C₆H₇NO₇S
Cas No.	152305-87-8
Smiles	O=C(ON1C(=O)CC(C1=O)S(=O)(=O)O)C
Relative Density.	1.80 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (421.6 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.2160 mL	21.0801 mL	42.1603 mL	210.8015 mL
5 mM	0.8432 mL	4.2160 mL	8.4321 mL	42.1603 mL
10 mM	0.4216 mL	2.1080 mL	4.2160 mL	21.0801 mL
20 mM	0.2108 mL	1.0540 mL	2.1080 mL	10.5401 mL
50 mM	0.0843 mL	0.4216 mL	0.8432 mL	4.2160 mL
100 mM	0.0422 mL	0.2108 mL	0.4216 mL	2.1080 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc