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RET-IN-3

Name: RET-IN-3
Brand: TargetMol
SKU: T9673
Price: 67 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9673Cas No. 2414374-53-9

RET-IN-3 is a RETV804M kinase inhibitor with potential anticancer activity for the study of non-small cell lung cancer.

RET-IN-3

🥰Excellent

Purity: 99.52%

Catalog No. T9673Cas No. 2414374-53-9

RET-IN-3 is a RETV804M kinase inhibitor with potential anticancer activity for the study of non-small cell lung cancer.

Pack Size	Price	Availability
1 mg	$67	In Stock
5 mg	$160	In Stock
10 mg	$253	In Stock
25 mg	$475	In Stock
50 mg	$749	In Stock
100 mg	$1,150	In Stock
200 mg	$1,550	In Stock
1 mL x 10 mM (in DMSO)	$177	In Stock

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Batch Information

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Purity:99.52%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	RET-IN-3 is a RETV804M kinase inhibitor with potential anticancer activity for the study of non-small cell lung cancer.
Targets&IC50	RETV804M:19 nM
In vitro	In comparison to wt-RET and KDR, RET-IN-3 demonstrates selectivity with folds of 16 and 410, respectively.[1].

Chemical Properties

Molecular Weight	339.39
Formula	C₁₈H₂₁N₅O₂
Cas No.	2414374-53-9
Smiles	CN(C)CCCNc1ccn2ncc(-c3ccc4OCOc4c3)c2n1
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (147.32 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9465 mL	14.7323 mL	29.4646 mL	147.3231 mL
5 mM	0.5893 mL	2.9465 mL	5.8929 mL	29.4646 mL
10 mM	0.2946 mL	1.4732 mL	2.9465 mL	14.7323 mL
20 mM	0.1473 mL	0.7366 mL	1.4732 mL	7.3662 mL
50 mM	0.0589 mL	0.2946 mL	0.5893 mL	2.9465 mL
100 mM	0.0295 mL	0.1473 mL	0.2946 mL	1.4732 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc