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TAK-448 acetate

Name: TAK-448 acetate
Brand: TargetMol
SKU: TP1093
Price: 98 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TP1093Cas No. 1470374-22-1

Alias TAK-448 acetate (1234319-68-6 Free base), MVT-602 acetate

TAK-448 acetate (MVT-602 acetate) is a synthetic peptide and small molecule KISS1R agonist with antitumor activity. It inhibits the proliferation of VCaP cells and is useful in prostate cancer research.

TAK-448 acetate

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Purity: 99.88%

Catalog No. TP1093Alias TAK-448 acetate (1234319-68-6 Free base), MVT-602 acetateCas No. 1470374-22-1

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$98	-	In Stock
5 mg	$247	-	In Stock
10 mg	$396	-	In Stock
25 mg	$648	-	In Stock
50 mg	$912	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.88%

Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description	TAK-448 acetate (MVT-602 acetate) is a synthetic peptide and small molecule KISS1R agonist with antitumor activity. It inhibits the proliferation of VCaP cells and is useful in prostate cancer research.
Targets&IC50	KISS1R:632 pM, KISS1R:460 pM
In vivo	A single injection of TAK-448 significantly increases plasma levels of follicle-stimulating hormone and testosterone (T) in male rats. In the androgen-sensitive prostate cancer model of male rats with VCaP xenografts, TAK-448 (0.01, 0.03, 0.3, 3 mg/kg; i.h.; 0,28 days) exhibits greater anti-tumor effects[1].
Synonyms	TAK-448 acetate (1234319-68-6 Free base), MVT-602 acetate

Chemical Properties

Molecular Weight	1285.41
Formula	C₆₀H₈₄N₁₆O₁₆
Cas No.	1470374-22-1
Smiles	CC(O)=O.CNC(=N)NCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](Cc1ccc(O)cc1)NC(C)=O)[C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O
Relative Density.	no data available
Sequence	Ac-{d-Tyr}-{Hyp}-NTF-{Aza-Gly}-L-{Arg(Me)}-W-NH2

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (62.24 mM), Sonication is recommended.

H2O: 30 mg/mL (23.34 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (2.57 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	0.7780 mL	3.8898 mL	7.7796 mL	38.8981 mL
5 mM	0.1556 mL	0.7780 mL	1.5559 mL	7.7796 mL
10 mM	0.0778 mL	0.3890 mL	0.7780 mL	3.8898 mL
20 mM	0.0389 mL	0.1945 mL	0.3890 mL	1.9449 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0156 mL	0.0778 mL	0.1556 mL	0.7780 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc