Sinapine hydroxide

Name: Sinapine hydroxide
Brand: TargetMol
SKU: T38606
Rating: 4.5 (1 reviews)

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Catalog No. T38606Cas No. 122-30-5

Sinapine hydroxide, an alkaloid derived from the seeds of cruciferous plants, demonstrates a variety of beneficial properties including anti-inflammatory, anti-oxidant, anti-tumor, anti-angiogenic, and radio-protective effects. Additionally, it acts as an inhibitor of acetylcholinesterase (AChE), making it valuable for researching neurodegenerative conditions such as Alzheimer's disease, ataxia, myasthenia gravis, and Parkinson's disease[4].

Sinapine hydroxide

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Catalog No. T38606Cas No. 122-30-5

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
25 mg	$1,520	Inquiry	Inquiry

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Product Introduction

Bioactivity

Description	Sinapine hydroxide, an alkaloid derived from the seeds of cruciferous plants, demonstrates a variety of beneficial properties including anti-inflammatory, anti-oxidant, anti-tumor, anti-angiogenic, and radio-protective effects. Additionally, it acts as an inhibitor of acetylcholinesterase (AChE), making it valuable for researching neurodegenerative conditions such as Alzheimer's disease, ataxia, myasthenia gravis, and Parkinson's disease[4].
In vitro	Sinapine (6 or 60 μM; 1 h) effectively mitigates mitochondrial oxidative stress in cardiomyocytes, triggered by H2O2 and antimycin A[1]. Additionally, at concentrations ranging from 10-200 μM over 24 hours, it suppresses Caco-2 cell proliferation dose-responsively with minimal toxicity, enhances doxorubicin uptake by reducing P-glycoprotein (P-gp) levels, and significantly diminishes FRS2α and ERK1/2 phosphorylation[3].
In vivo	Sinapine mitigates non-alcoholic fatty liver disease (NAFLD) in mice through alterations in gut microbiota composition[2].

Chemical Properties

Molecular Weight	327.377
Formula	C₁₆H₂₅NO₆
Cas No.	122-30-5
Smiles	[OH-].COc1cc(C=CC(=O)OCC[N+](C)(C)C)cc(OC)c1O \|w:7.6\|

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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You can also refer to dose conversion for different animals. More Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc