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Sinapine hydroxide

Catalog No. T38606 CAS 122-30-5

Sinapine hydroxide, an alkaloid derived from the seeds of cruciferous plants, demonstrates a variety of beneficial properties including anti-inflammatory, anti-oxidant, anti-tumor, anti-angiogenic, and radio-protective effects. Additionally, it acts as an inhibitor of acetylcholinesterase (AChE), making it valuable for researching neurodegenerative conditions such as Alzheimer’s disease, ataxia, myasthenia gravis, and Parkinson’s disease[4].

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Sinapine hydroxide, CAS 122-30-5

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25 mg	Inquiry	$ 1,520.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Sinapine hydroxide, an alkaloid derived from the seeds of cruciferous plants, demonstrates a variety of beneficial properties including anti-inflammatory, anti-oxidant, anti-tumor, anti-angiogenic, and radio-protective effects. Additionally, it acts as an inhibitor of acetylcholinesterase (AChE), making it valuable for researching neurodegenerative conditions such as Alzheimer’s disease, ataxia, myasthenia gravis, and Parkinson’s disease[4].
In vitro	Sinapine (6 or 60 μM; 1 h) effectively mitigates mitochondrial oxidative stress in cardiomyocytes, triggered by H2O2 and antimycin A[1]. Additionally, at concentrations ranging from 10-200 μM over 24 hours, it not only suppresses the proliferation of Caco-2 cells in a dose-responsive manner with minimal toxicity but also enhances doxorubicin uptake in these cells by reducing P-glycoprotein (P-gp) levels[3]. Furthermore, sinapine significantly diminishes the phosphorylation of FRS2α and ERK1/2 under similar conditions[3].
In vivo	Sinapine mitigates non-alcoholic fatty liver disease (NAFLD) in mice through alterations in gut microbiota composition[2].

Molecular Weight	327.377
Formula	C16H25NO6
CAS No.	122-30-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Boulghobra D, et, al. Sinapine, but not sinapic acid, counteracts mitochondrial oxidative stress in cardiomyocytes. Redox Biol. 2020 Jul;34:101554. 2. Li Y, et, al. Sinapine reduces non-alcoholic fatty liver disease in mice by modulating the composition of the gut microbiota. Food Funct. 2019 Jun 19;10(6):3637-3649. 3. Guo Y, et, al. Sinapine as an active compound for inhibiting the proliferation of Caco-2 cells via downregulation of P-glycoprotein. Food Chem Toxicol. 2014 May;67:187-92. 4. Yates K, et, al. Determination of sinapine in rapeseed pomace extract: Its antioxidant and acetylcholinesterase inhibition properties. Food Chem. 2019 Mar 15;276:768-775.

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Keywords

Sinapine hydroxide 122-30-5 Sinapine Hydroxide inhibitor inhibit

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