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NSC49652

Name: NSC49652
Brand: TargetMol
SKU: T28206
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T28206Cas No. 908563-68-8

Alias NSC-49652, NSC 49652

NSC49652 triggers apoptotic cell death dependent on p75NTR and JNK activity in neurons and melanoma cells, and inhibits tumor growth in a melanoma mouse model.

NSC49652

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Purity: 98.98%

Catalog No. T28206Alias NSC-49652, NSC 49652Cas No. 908563-68-8

NSC49652 triggers apoptotic cell death dependent on p75NTR and JNK activity in neurons and melanoma cells, and inhibits tumor growth in a melanoma mouse model.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$31	In Stock	In Stock
5 mg	$72	In Stock	In Stock
10 mg	$122	In Stock	In Stock
25 mg	$247	In Stock	In Stock
50 mg	$392	In Stock	In Stock
100 mg	$589	In Stock	In Stock
500 mg	$1,280	-	In Stock
1 mL x 10 mM (in DMSO)	$79	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.98%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

NSC49652 AI Summary

NSC49652 has bioactivities as an inhibitor in various assays, demonstrating potency in targeting multiple biological pathways and enzymes, including human Jumonji Domain Containing 2E, ROR gamma transcriptional activity, Schistosoma Mansoni Peroxiredoxins, Bacillus subtilis Sfp phosphopantetheinyl transferase, Influenza NS1 protein function, Histone Lysine Methyltransferase G9a, vitamin D receptor (VDR), firefly luciferase, ClpP activators, gsp mutation responsible for Fibrous Dysplasia/McCune-Albright Syndrome, human tyrosyl-DNA phosphodiesterase 1 (TDP1), and PTHR inhibitors. It inhibits mushroom tyrosinase activity by 49.3%, suggesting potential applications in skincare or cosmetic products targeting hyperpigmentation or melasma. However, NSC49652 shows no significant antibacterial or antifungal activities with MIC values greater than 10000.0 nM and exhibits no cytotoxicity against HEK293 cells, given a CC50 value exceeding 10000.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	NSC49652 triggers apoptotic cell death dependent on p75NTR and JNK activity in neurons and melanoma cells, and inhibits tumor growth in a melanoma mouse model.
Synonyms	NSC-49652, NSC 49652

Chemical Properties

Molecular Weight	225.24
Formula	C₁₄H₁₁NO₂
Cas No.	908563-68-8
Smiles	Oc1ccccc1C(=O)\C=C\c1cccnc1
Relative Density.	1.241 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (221.99 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.4397 mL	22.1985 mL	44.3971 mL	221.9854 mL
5 mM	0.8879 mL	4.4397 mL	8.8794 mL	44.3971 mL
10 mM	0.4440 mL	2.2199 mL	4.4397 mL	22.1985 mL
20 mM	0.2220 mL	1.1099 mL	2.2199 mL	11.0993 mL
50 mM	0.0888 mL	0.4440 mL	0.8879 mL	4.4397 mL
100 mM	0.0444 mL	0.2220 mL	0.4440 mL	2.2199 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc