Biatractylolide is a natural product that can be used for research related to the life sciences.

In PC12 cells, Biatractylolide significantly attenuated Aβ₁₋₄₂-induced cytotoxicity (20, 40, and 80 μM, 24 h), increased cell viability, reduced ROS levels, and suppressed apoptosis-related protein expression (e.g., cleaved caspase-3 and Bax/Bcl-2 ratio), indicating antioxidant and anti-apoptotic properties[1].

In SD rats with hippocampal Aβ₁₋₄₂-induced Alzheimer's disease model, oral administration of Biatractylolide (20 and 40 mg/kg/day, for 14 days) improved cognitive function (shortened escape latency in the Morris water maze), and reduced expression of p-Tau and cleaved caspase-3 in hippocampal tissue, suggesting neuroprotective and anti-Alzheimer’s potential[1].