Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PIP4K-IN-a131 is a selective inhibitor of PIP4K lipid kinases, demonstrating IC50 values of 1.9 μM for PIP4K2A and 0.6 μM for PIP4Ks. It exhibits cancer-selective lethality by simultaneously blocking the lipid kinase PIP4Ks and mitotic pathways.
Pack Size | Availability | Price/USD | Quantity |
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5 mg | 5 days | $ 247.00 |
Description | PIP4K-IN-a131 is a selective inhibitor of PIP4K lipid kinases, demonstrating IC50 values of 1.9 μM for PIP4K2A and 0.6 μM for PIP4Ks. It exhibits cancer-selective lethality by simultaneously blocking the lipid kinase PIP4Ks and mitotic pathways. |
Targets&IC50 | PIP4K2A:1.9 µM (IC50), PIP4Ks:0.6 µM (IC50) |
In vitro | PIP4K-IN-a131 (0-100 μM; 72?hours) is a potent antiproliferative agent with a clear selectivity toward cancer cells killing[1]. PIP4K-IN-a131 eliminates cancer cells via a dual-inhibitory mechanism[1]. PIP4K-IN-a131 causes inhibition of the PI3K/Akt/mTOR pathway only in normal BJ cells, but not in transformed counterparts[1]. Inhibition of PIP4Ks by PIP4K-IN-a131 arrests normal cells at the G1/S phase of the cell cycle by suppressing the PI3K/Akt/mTOR signaling pathway via transcriptional upregulation of PIK3IP1[1]. Cell Proliferation Assay[1]Cell Line: Normal and transformed BJ cells Concentration: 0-100 μM (MTT assay) Incubation Time: 72?hours Result: Selective killed cancer cells. RT-PCR[1]Cell Line: BJ cells Concentration: 5?μM Incubation Time: 24?hours Result: Induced the upregulation of PIK3IP1 mRNA levels. |
Synonyms | PIP4K-IN-a131 |
Molecular Weight | 295.345 |
Formula | C20H13N3 |
CAS No. | 2055405-95-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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PIP4K-IN-a131 2055405-95-1 PIP-4K-IN-a131 PIP4K IN a131 PIP4KINa131 inhibitor inhibit