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PIP4K-IN-a131

Name: PIP4K-IN-a131
Brand: TargetMol
SKU: T39452
Rating: 4.5 (1 reviews)

(Synonyms: PIP4K-IN-a131) Copy Product Info

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Synonyms: PIP4K-IN-a131

Catalog No. T39452 Copy Product Info

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PIP4K-IN-a131 is a selective inhibitor of phosphatidylinositol-5-phosphate 4-kinase type 2 alpha (PIP4K2A), with inhibitory activity in the micromolar range against PIP4K2A and the broader PIP4K family (IC₅₀ ≈ 1.9 μM and 0.6 μM, respectively). PIP4K-IN-a131 suppresses PIP4K-mediated lipid signaling and cell cycle–related processes, and exhibits antiproliferative effects in cancer cells.

Cas No. 2055405-95-1

Pack Size	Price	USA Stock	Global Stock	Quantity
5 mg	$650	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Appearance:Solid

Color:Yellow

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COA

Product Introduction

Bioactivity

Description	PIP4K-IN-a131 is a selective inhibitor of phosphatidylinositol-5-phosphate 4-kinase type 2 alpha (PIP4K2A), with inhibitory activity in the micromolar range against PIP4K2A and the broader PIP4K family (IC₅₀ ≈ 1.9 μM and 0.6 μM, respectively). PIP4K-IN-a131 suppresses PIP4K-mediated lipid signaling and cell cycle–related processes, and exhibits antiproliferative effects in cancer cells.
Targets & IC50	PIP4K2A:1.9 μM, PIP4Ks:0.6 μM
In vitro	PIP4K-IN-a131 (0–100 μM; 72 hours) is an effective antiproliferative agent that exhibits marked selectivity for killing cancer cells. PIP4K-IN-a131 eliminates cancer cells through a dual inhibition mechanism. PIP4K-IN-a131 inhibits the PI3K/Akt/mTOR pathway only in normal BJ cells, but has no inhibitory effect in their transformed counterparts. PIP4K-IN-a131 inhibits the PI3K/Akt/mTOR signaling pathway by upregulating PIK3IP1 transcription through its inhibition of PIP4K, causing normal cells to arrest in the G1/S phase of the cell cycle [1].
Synonyms	PIP4K-IN-a131

Chemical Properties

Molecular Weight	295.35
Formula	C₂₀H₁₃N₃
Cas No.	2055405-95-1
Smiles	C(=C\C=1C2=C(C=CC1)C=NC=C2)(\C#N)/C=3C=4C(NC3)=CC=CC4
Relative Density.	1.308 g/cm3 (Predicted)

Storage & Solubility Information

Storage

The compound is unstable in solution. Please use soon Powder: -20°C for 3 years Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50.00 mg/mL (169.29 mM), The compound is unstable in solution. Please use soon.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3858 mL	16.9291 mL	33.8581 mL	169.2907 mL
5 mM	0.6772 mL	3.3858 mL	6.7716 mL	33.8581 mL
10 mM	0.3386 mL	1.6929 mL	3.3858 mL	16.9291 mL
20 mM	0.1693 mL	0.8465 mL	1.6929 mL	8.4645 mL
50 mM	0.0677 mL	0.3386 mL	0.6772 mL	3.3858 mL
100 mM	0.0339 mL	0.1693 mL	0.3386 mL	1.6929 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc