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PIP4K-IN-a131
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Catalog No. T39452Cas No. 2055405-95-1
Alias PIP4K-IN-a131
PIP4K-IN-a131 is a selective inhibitor of PIP4K lipid kinases, demonstrating IC50 values of 1.9 μM for PIP4K2A and 0.6 μM for PIP4Ks. It exhibits cancer-selective lethality by simultaneously blocking the lipid kinase PIP4Ks and mitotic pathways.
PIP4K-IN-a131
Copy Product Info😃Good
Catalog No. T39452Alias PIP4K-IN-a131Cas No. 2055405-95-1
PIP4K-IN-a131 is a selective inhibitor of PIP4K lipid kinases, demonstrating IC50 values of 1.9 μM for PIP4K2A and 0.6 μM for PIP4Ks. It exhibits cancer-selective lethality by simultaneously blocking the lipid kinase PIP4Ks and mitotic pathways.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $247 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
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Chemical Properties
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| Description | PIP4K-IN-a131 is a selective inhibitor of PIP4K lipid kinases, demonstrating IC50 values of 1.9 μM for PIP4K2A and 0.6 μM for PIP4Ks. It exhibits cancer-selective lethality by simultaneously blocking the lipid kinase PIP4Ks and mitotic pathways. |
| Targets&IC50 | PIP4K2A:1.9 µM (IC50), PIP4Ks:0.6 µM (IC50) |
| In vitro | PIP4K-IN-a131 (0-100 μM; 72 hours) is a potent antiproliferative agent with selectivity for killing cancer cells via a dual-inhibitory mechanism. It inhibits the PI3K/Akt/mTOR pathway in normal BJ cells but not in transformed counterparts, causing G1/S phase arrest by transcriptionally upregulating PIK3IP1. In a Cell Proliferation Assay using normal and transformed BJ cells, PIP4K-IN-a131 (0-100 μM) selectively killed cancer cells after 72 hours. In RT-PCR, BJ cells treated with PIP4K-IN-a131 (5 μM; 24 hours) showed upregulation of PIK3IP1 mRNA levels. |
| Synonyms | PIP4K-IN-a131 |
| Molecular Weight | 295.345 |
| Formula | C20H13N3 |
| Cas No. | 2055405-95-1 |
| Smiles | N#C\C(=C/c1cccc2cnccc12)c1c[nH]c2ccccc12 |
| Relative Density. | 1.308 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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