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BC-23

Name: BC-23
Brand: TargetMol
SKU: T26754
Price: 100 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T26754Cas No. 6298-15-3

Alias NSC-45382, NSC45382, NSC 45382, BC23, BC 23

BC-23 (NSC 45382) is a potent proteasome inhibitor with antitumor and antimicrobial activity, inhibiting the CT-L activity of the proteasome and used in the study of leukemias, lymphomas, gliomas, breast cancer, and small cell lung cancer.

BC-23

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Purity: 99.99%

Catalog No. T26754Alias NSC-45382, NSC45382, NSC 45382, BC23, BC 23Cas No. 6298-15-3

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$100	-	In Stock
5 mg	$197	-	In Stock
10 mg	$318	-	In Stock
25 mg	$575	-	In Stock
50 mg	$860	-	In Stock
100 mg	$1,290	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.99%

Appearance:Solid

Color:Orange

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Product Introduction

BC-23 AI Summary

BC-23 exhibits a broad range of bioactivities, including potent inhibitory effects on chymotrypsin-like, trypsin-like, and PGPH activities of the rabbit 26S proteasome, with varied IC50 values. It also inhibits 26S proteasome-mediated chymotrypsin-like activity in human MCF7 cells. Additionally, BC-23 shows strong inhibition of calpain (IC50 > 30000.0 nM) and moderate inhibitory activity against chymotrypsin-like activity of the human 20S proteasome (IC50 18560.0 nM). It affects multiple molecular pathways, including the beta catenin/Tcf4 and Wnt/beta-catenin transcriptional activities with IC50 values of 1700.0 nM and 2300.0 nM, respectively. The compound also demonstrates antiproliferative activity across various human cancer cell lines such as KBVIN, KB, DU145, A549, and MCF7, with IC50 values ranging from 9570.0 nM to 12190.0 nM, including specific inhibition of MCF7 cell growth (IC50 1960.0 nM). Moreover, BC-23 inhibits enzymes such as HSD17B4, Cytochrome P450 (2C19, 2D6, 2C9), ALDH1A1, hydroxyacyl-Coenzyme A dehydrogenase, and HPGD. It also shows activity in erasing genomic imprints and modulating the Hypoxia Response Element Signaling Pathway, and demonstrates varying potency in inhibiting the growth of several human tumor cell lines, indicating its potential as a multi-target anticancer agent..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	BC-23 (NSC 45382) is a potent proteasome inhibitor with antitumor and antimicrobial activity, inhibiting the CT-L activity of the proteasome and used in the study of leukemias, lymphomas, gliomas, breast cancer, and small cell lung cancer.
Synonyms	NSC-45382, NSC45382, NSC 45382, BC23, BC 23

Chemical Properties

Molecular Weight	439.87
Formula	C₂₁H₁₄ClN₃O₄S
Cas No.	6298-15-3
Smiles	O=C1C=2C(C(=O)C(Cl)=C1NC3=CC=C(S(NC4=CC=CC=N4)(=O)=O)C=C3)=CC=CC2
Relative Density.	1.56 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 20 mg/mL (45.47 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2734 mL	11.3670 mL	22.7340 mL	113.6699 mL
5 mM	0.4547 mL	2.2734 mL	4.5468 mL	22.7340 mL
10 mM	0.2273 mL	1.1367 mL	2.2734 mL	11.3670 mL
20 mM	0.1137 mL	0.5683 mL	1.1367 mL	5.6835 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc