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BC-23

Name: BC-23
Brand: TargetMol
SKU: T26754
Rating: 4.5 (1 reviews)

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Catalog No. T26754Cas No. 6298-15-3

Alias NSC-45382, NSC45382, NSC 45382, BC23, BC 23

BC-23 (NSC 45382) is a potent proteasome inhibitor with antitumor and antimicrobial activity, inhibiting the CT-L activity of the proteasome and used in the study of leukemias, lymphomas, gliomas, breast cancer, and small cell lung cancer.

BC-23

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Catalog No. T26754Alias NSC-45382, NSC45382, NSC 45382, BC23, BC 23Cas No. 6298-15-3

Pack Size	Price	Availability
1 mg	$100	6-8 weeks
5 mg	$197	6-8 weeks
10 mg	$318	6-8 weeks
25 mg	$575	6-8 weeks
50 mg	$860	6-8 weeks
100 mg	$1,290	6-8 weeks

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	BC-23 (NSC 45382) is a potent proteasome inhibitor with antitumor and antimicrobial activity, inhibiting the CT-L activity of the proteasome and used in the study of leukemias, lymphomas, gliomas, breast cancer, and small cell lung cancer.
Synonyms	NSC-45382, NSC45382, NSC 45382, BC23, BC 23

Chemical Properties

Molecular Weight	439.87
Formula	C₂₁H₁₄ClN₃O₄S
Cas No.	6298-15-3
Smiles	O=C1C=2C(C(=O)C(Cl)=C1NC3=CC=C(S(NC4=CC=CC=N4)(=O)=O)C=C3)=CC=CC2
Relative Density.	1.56 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 20 mg/mL (45.47 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2734 mL	11.3670 mL	22.7340 mL	113.6699 mL
5 mM	0.4547 mL	2.2734 mL	4.5468 mL	22.7340 mL
10 mM	0.2273 mL	1.1367 mL	2.2734 mL	11.3670 mL
20 mM	0.1137 mL	0.5683 mL	1.1367 mL	5.6835 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc