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(-)-Syringaresinol

Name: (-)-Syringaresinol
Brand: TargetMol
SKU: TJS0487
Price: 98 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TJS0487Cas No. 6216-81-5

Alias Lirioresinol b, DL-Syringaresinol

(-)-Syringaresinol (DL-Syringaresinol) is derived from the stems of Annona Montana. (-)-Syringaresinol inhibits the proliferation of human promyelocytic HL-60 cells through G1 arrest and induction of apoptosis and possesses anti-cancer activity.

(-)-Syringaresinol

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Purity: 99.83%

Catalog No. TJS0487Alias Lirioresinol b, DL-SyringaresinolCas No. 6216-81-5

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$38	In Stock	In Stock
2 mg	$57	-	In Stock
5 mg	$98	In Stock	In Stock
10 mg	Preferential	-	In Stock
25 mg	Preferential	-	In Stock
50 mg	Preferential	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.83%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

(-)-Syringaresinol AI Summary

(-)-Syringaresinol exhibits a range of bioactivities, including significant antiinflammatory, antiplasmodial, anticancer, and antineuroinflammatory effects. In human neutrophils, it inhibits formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B-induced elastase release with an IC50 greater than 50000.0 nM and superoxide anion generation with IC50 values of 39870.0 nM and 40200.0 nM. It demonstrates antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D6 with an IC50 value greater than 10.0 µg/mL. In terms of antiinflammatory activity, the compound inhibits lipopolysaccharide-induced nitric oxide production in mouse BV2 cells with IC50 values of 13480.0 nM and 27530.0 nM after 24 hours, and interleukin-1beta production in mouse RAW264.7 cells with an IC50 greater than 50000.0 nM. Additionally, it displays anticancer activity against human A549, SK-MEL-2, and XF498 cells with IC50 values exceeding 30000.0 nM, 14470.0 nM, and 8820.0 nM, respectively, while showing less activity against SKOV3 cells with an IC50 value of over 30000.0 nM. (-)-Syringaresinol is also active in inducing supercoiled pSP64 plasmid DNA cleavage, enhancing the nicked form by over 50% at a concentration of 1 µM, as shown by agarose gel electrophoresis. Furthermore, it exhibits cytotoxicity against lipopolysaccharide-stimulated mouse BV2 cells at 20 µM with a relative activity of 110.1% as assessed by MTT assay, and inhibits nitric oxide production in these cells with an IC50 greater than 100000.0 nM after 24 hours..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	(-)-Syringaresinol (DL-Syringaresinol) is derived from the stems of Annona Montana. (-)-Syringaresinol inhibits the proliferation of human promyelocytic HL-60 cells through G1 arrest and induction of apoptosis and possesses anti-cancer activity.
Synonyms	Lirioresinol b, DL-Syringaresinol

Chemical Properties

Molecular Weight	418.44
Formula	C₂₂H₂₆O₈
Cas No.	6216-81-5
Smiles	[H][C@@]12CO[C@@H](c3cc(OC)c(O)c(OC)c3)[C@]1([H])CO[C@H]2c1cc(OC)c(O)c(OC)c1
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (215.08 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.89 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3898 mL	11.9491 mL	23.8983 mL	119.4914 mL
5 mM	0.4780 mL	2.3898 mL	4.7797 mL	23.8983 mL
10 mM	0.2390 mL	1.1949 mL	2.3898 mL	11.9491 mL
20 mM	0.1195 mL	0.5975 mL	1.1949 mL	5.9746 mL
50 mM	0.0478 mL	0.2390 mL	0.4780 mL	2.3898 mL
100 mM	0.0239 mL	0.1195 mL	0.2390 mL	1.1949 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc