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8-Bromo-cAMP sodium salt

Name: 8-Bromo-cAMP sodium salt
Brand: TargetMol
SKU: T6747
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6747Cas No. 76939-46-3

Alias 8-Bromo-cAMP(sodium salt), 8-Br-Camp sodium salt

8-Bromo-cAMP sodium salt (8-Br-Camp sodium salt) is a long-acting derivative of cyclic AMP. It is an activator of cyclic AMP-dependent protein kinase（PKA）, but resistant to degradation by cyclic AMP phosphodiesterase.

8-Bromo-cAMP sodium salt

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Purity: 99.94%

Catalog No. T6747Alias 8-Bromo-cAMP(sodium salt), 8-Br-Camp sodium saltCas No. 76939-46-3

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$41	In Stock	In Stock
10 mg	$58	In Stock	In Stock
25 mg	$78	In Stock	In Stock
50 mg	$132	In Stock	In Stock
100 mg	$227	In Stock	In Stock
200 mg	$346	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$46	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.94%

Color:White

Resource Download

COA HPLC HNMR

Product Introduction

8-Bromo-cAMP sodium salt AI Summary

8-Bromo-cAMP sodium salt exhibits antiplasmodial activity against various strains of Plasmodium falciparum, with IC50 values ranging from 5011.87 nM to 12589.25 nM after 72 hours, as determined by the SYBR green assay. It shows significant bioactivity in various assays, including inhibition of cell surface uPA generation and interactions with targets such as tyrosyl-DNA phosphodiesterase 1 (TDP1) and cAMP-regulated guanine nucleotide exchange factors. Moreover, it induces the secretion of radioiodine from the thyroid in iodine-deficient mice, demonstrating dose-dependent increases in blood [125I] levels. 8-Bromo-cAMP sodium salt also exhibits both activation and inhibition of key proteins in cellular signaling, activating rat CNGA2 channels and human PKAR2alpha and PKAR1alpha, while inhibiting the binding of 8Fluo-cAMP to EPAC2 and EPAC1 proteins. These characteristics suggest that 8-Bromo-cAMP sodium salt has potential applications in modulating cellular signaling processes and ion channel functions..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	8-Bromo-cAMP sodium salt (8-Br-Camp sodium salt) is a long-acting derivative of cyclic AMP. It is an activator of cyclic AMP-dependent protein kinase（PKA）, but resistant to degradation by cyclic AMP phosphodiesterase.
Targets&IC50	PKA:0.05 μM(Ka)
In vitro	METHODS: Endothelial HUVECs were treated with 8-Bromo-cAMP sodium salt (100 µM) for 3 h. Cell migration was detected by Boyden Chamber assay. RESULTS: Increased cell migration was observed when conditioned media from MC3T3-E1 cells exposed to 8-Bromo-cAMP was supplemented with HUVECs. In contrast, conditioned medium from control untreated cells lacked this activity. [1] METHODS: The leukemia cell line AML193 was treated with 8-Bromo-cAMP sodium salt (1 mM) or IL-3 (500 ng/mL) for 1-15 min, and target protein expression levels were detected by Western Blot. RESULTS: In growth-arrested AML193 cells, the maximal effect of IL-3 on Erk1,2 phosphorylation was time-dependent and occurred within a time window of 5-15 min after the addition of growth factors. 8-Bromo-cAMP also induced Erk1,2 phosphorylation in these cells, with a maximal stimulation observable between 1-5 min. [2]
In vivo	METHODS: To evaluate the effect of cAMP/PCA on angiogenesis and VM in CRC cells, 8-Bromo-cAMP sodium salt (60 mg/kg) was intraperitoneally injected into BALB/c mice bearing CT26 tumor tissues once a day for seven days. RESULTS: 8-Bromo-cAMP treatment significantly reduced the number of tumors. 8-Bromo-cAMP treatment inhibited angiogenesis and VM. 8-Bromo-cAMP acted through the cAMP/PKA-ERK pathway and EMT process in CRC. [3]
Synonyms	8-Bromo-cAMP(sodium salt), 8-Br-Camp sodium salt

Chemical Properties

Molecular Weight	430.08
Formula	C₁₀H₁₀BrN₅NaO₆P
Cas No.	76939-46-3
Smiles	[Na+].Nc1ncnc2n(C3OC4COP([O-])(=O)OC4C3O)c(Br)nc12
Relative Density.	no data available

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 80 mg/mL (186.01 mM), Heating is recommended.

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 128 mg/mL (297.62 mM), Sonication is recommended.

In Vivo Formulation

5% DMSO＋40% PEG300＋5% Tween-80＋50% ddH2O: 0.624

PBS: 100 mg/mL (232.51 mM)

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3251 mL	11.6257 mL	23.2515 mL	116.2574 mL
5 mM	0.4650 mL	2.3251 mL	4.6503 mL	23.2515 mL
10 mM	0.2325 mL	1.1626 mL	2.3251 mL	11.6257 mL
20 mM	0.1163 mL	0.5813 mL	1.1626 mL	5.8129 mL
50 mM	0.0465 mL	0.2325 mL	0.4650 mL	2.3251 mL
100 mM	0.0233 mL	0.1163 mL	0.2325 mL	1.1626 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc