Piperidine-GNE-049-N-Boc

Name: Piperidine-GNE-049-N-Boc
Brand: TargetMol
SKU: T39352
Rating: 4.5 (1 reviews)

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Catalog No. T39352Cas No. 1936431-36-5

Piperidine-GNE-049-N-Boc is a ligand that specifically binds to the target protein dCBP, facilitating its degradation by a selective and potent heterobifunctional degrader, p300/CBP.

Piperidine-GNE-049-N-Boc

😃Good

Catalog No. T39352Cas No. 1936431-36-5

Piperidine-GNE-049-N-Boc is a ligand that specifically binds to the target protein dCBP, facilitating its degradation by a selective and potent heterobifunctional degrader, p300/CBP.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$788	Inquiry	Inquiry
10 mg	$1,360	Inquiry	Inquiry
50 mg	Inquiry	Inquiry	Inquiry
100 mg	Inquiry	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	Piperidine-GNE-049-N-Boc is a ligand that specifically binds to the target protein dCBP, facilitating its degradation by a selective and potent heterobifunctional degrader, p300/CBP.
In vitro	Piperidine-GNE-049-N-Boc (S17) is a precursor used in the synthesis of dCBP-1[1].

Chemical Properties

Molecular Weight	567.686
Formula	C₃₀H₃₉F₂N₇O₂
Cas No.	1936431-36-5
Smiles	Cn1cc(cn1)-c1cc2CCCN(c3nn(C4CCNCC4)c4CCN(Cc34)C(=O)OC(C)(C)C)c2cc1C(F)F
Relative Density.	1.37 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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