9-Methoxyellipticine is a natural alkaloid and potent c-Kit kinase inhibitor exhibiting cytotoxic properties. It inhibits c-kit(wt) and c-Kit(D816V) with IC₅₀ values of 0.8 and 0.6 µM respectively, making it suitable for leukaemia research.

9-Methoxyellipticine inhibits proliferation of Ba/F3 cells in the presence of the c-Kit ligand SCF and Ba/F3 cells expressing c-KitD816V(IC50s = 0.5 and 0.3 μM, respectively).2It also increases survival in a variety of rodent tumor models.[1]