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Damulin A
🥰Excellent
Catalog No. TN3758Cas No. 1202868-74-3
Damulin A is an active dammarane-type saponin isolated from Gynostemma pentaphyllum and belongs to a group of structurally related compounds whose anticancer structure–activity relationships have been deeply explored. Comparative investigations reveal that double bonds positioned at C20(21) and C20(22) and hydroxyl modification at C-2 significantly contribute to cytotoxicity, as evidenced by proliferation inhibition in A549 cells. These findings confirm the importance of Damulin A within the broader context of Gynostemma-derived anticancer leads.
Damulin A
🥰Excellent
Purity: 98.33%
Catalog No. TN3758Cas No. 1202868-74-3
Damulin A is an active dammarane-type saponin isolated from Gynostemma pentaphyllum and belongs to a group of structurally related compounds whose anticancer structure–activity relationships have been deeply explored. Comparative investigations reveal that double bonds positioned at C20(21) and C20(22) and hydroxyl modification at C-2 significantly contribute to cytotoxicity, as evidenced by proliferation inhibition in A549 cells. These findings confirm the importance of Damulin A within the broader context of Gynostemma-derived anticancer leads.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $148 | - | In Stock | |
| 5 mg | $368 | - | In Stock | |
| 10 mg | $550 | - | In Stock | |
| 25 mg | $990 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:98.33%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Damulin A is an active dammarane-type saponin isolated from Gynostemma pentaphyllum and belongs to a group of structurally related compounds whose anticancer structure–activity relationships have been deeply explored. Comparative investigations reveal that double bonds positioned at C20(21) and C20(22) and hydroxyl modification at C-2 significantly contribute to cytotoxicity, as evidenced by proliferation inhibition in A549 cells. These findings confirm the importance of Damulin A within the broader context of Gynostemma-derived anticancer leads. |
| In vitro | Damulin A exhibits anti-cancer activity and shows strong cytotoxicity against A549 cells (a human non-small cell lung cancer cell line) with an IC50 value of 59.2 μM [1]. |
| Molecular Weight | 783.01 |
| Formula | C42H70O13 |
| Cas No. | 1202868-74-3 |
| Smiles | C[C@]12[C@@]([C@]3(C)[C@@](CC1)(C(C)(C)[C@@H](O[C@H]4[C@H](O[C@@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O)[C@@H](O)[C@H](O)[C@@H](CO)O4)[C@H](O)C3)[H])(C[C@@H](O)[C@]6([C@@]2(C)CC[C@@H]6\C(=C\CC=C(C)C)\C)[H])[H] |
| Relative Density. | 1.31 g/cm3 (Predicted) |
| Color | White |
| Appearance | Solid |
Storage & Solubility Information
| Storage | keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 40 mg/mL (51.08 mM), Sonication is recommeded. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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