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MC4033

Name: MC4033
Brand: TargetMol
SKU: T78156
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T78156Cas No. 28532-21-0

MC4033 is a selective lysine acetyltransferase 8 (KAT8) inhibitor (IC50: 12.1 μM) with anticancer effects, induces apoptosis, and can be used for the study of non-small cell lung cancer.

MC4033

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Purity: 98.16%

Catalog No. T78156Cas No. 28532-21-0

MC4033 is a selective lysine acetyltransferase 8 (KAT8) inhibitor (IC50: 12.1 μM) with anticancer effects, induces apoptosis, and can be used for the study of non-small cell lung cancer.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$31	In Stock	In Stock
5 mg	$70	In Stock	In Stock
10 mg	$113	In Stock	In Stock
25 mg	$229	In Stock	In Stock
50 mg	$372	In Stock	In Stock
100 mg	$596	In Stock	In Stock
500 mg	$1,250	8-10 weeks	8-10 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.16%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	MC4033 is a selective lysine acetyltransferase 8 (KAT8) inhibitor (IC50: 12.1 μM) with anticancer effects, induces apoptosis, and can be used for the study of non-small cell lung cancer.
Targets&IC50	KAT8:12.1 μM
In vitro	MC4033 (10, 25, 50, and 100 μM; 72 hours) exhibited dose-dependent antiproliferative effects in HCT116, H1299, A549, and U937 cell lines. In U937 cells, the inhibition rate of cell proliferation was 70% at 50 μM and >80% at 100 μM[1].

Chemical Properties

Molecular Weight	295.29
Formula	C₁₆H₁₃N₃O₃
Cas No.	28532-21-0
Smiles	O=C(O)C1=CC=C(C=C1)N2N=C(C(=CC3=CC=CN3)C2=O)C

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 26.32 mg/mL (89.13 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 1.5 mg/mL (5.08 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3865 mL	16.9325 mL	33.8650 mL	169.3251 mL
5 mM	0.6773 mL	3.3865 mL	6.7730 mL	33.8650 mL
10 mM	0.3387 mL	1.6933 mL	3.3865 mL	16.9325 mL
20 mM	0.1693 mL	0.8466 mL	1.6933 mL	8.4663 mL
50 mM	0.0677 mL	0.3387 mL	0.6773 mL	3.3865 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc