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Clausine E

Name: Clausine E
Brand: TargetMol
SKU: TN6779
Price: 153 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN6779Cas No. 182261-83-2

Clausine E is an inhibitor of fat mass and obesity-associated protein (FTO) demethylase activity. The binding of Clausine E to FTO was driven by positive entropy and negative enthalpy changes.

Clausine E

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Purity: 98.77%

Catalog No. TN6779Cas No. 182261-83-2

Clausine E is an inhibitor of fat mass and obesity-associated protein (FTO) demethylase activity. The binding of Clausine E to FTO was driven by positive entropy and negative enthalpy changes.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$153	In Stock	In Stock
5 mg	$380	In Stock	In Stock
10 mg	$565	In Stock	In Stock
25 mg	$890	In Stock	In Stock
50 mg	$1,230	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$392	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.77%

Appearance:Solid

Color:White

Resource Download

COA HPLC HNMR

Product Introduction

Clausine E AI Summary

Clausine E exhibits antiproliferative and cytotoxic activities across a variety of human cancer cell lines, including Mes-sa, MCF7, HCT116, SW48, SW480, HepG2, HeLa, CNE2, T98G, MDA-MB-231, human NCI-H187 cells, human KB cells, and african green monkey Vero cells. The compound shows varying IC50 values, ranging from 13,300.0 nM to 152,050.0 nM, depending on the cell line and assay conditions. Moreover, Clausine E induces cell cycle arrest at different phases (G0/G1, S, G2/M) in cells such as HCT116, SW48, SW480, and HepG2. Notably, it exhibits significant bioactivity by inhibiting EBV-early antigen activation in Raji cells, demonstrating maximal inhibition of 100.0% at 0.32 nmol, and shows cytotoxic effects on these cells. It also inhibits the demethylation activity of the FTO enzyme with an IC50 value of 27,790.0 nM. Taken together, these multifaceted activities suggest that Clausine E poses potential therapeutic effects on cell proliferation, survival, and specific enzymatic processes..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Clausine E is an inhibitor of fat mass and obesity-associated protein (FTO) demethylase activity. The binding of Clausine E to FTO was driven by positive entropy and negative enthalpy changes.

Chemical Properties

Molecular Weight	241.24
Formula	C₁₄H₁₁NO₃
Cas No.	182261-83-2
Smiles	OC1=C2C(C=3C(N2)=CC=CC3)=CC(C(OC)=O)=C1
Relative Density.	1.400 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (227.99 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.1452 mL	20.7262 mL	41.4525 mL	207.2625 mL
5 mM	0.8290 mL	4.1452 mL	8.2905 mL	41.4525 mL
10 mM	0.4145 mL	2.0726 mL	4.1452 mL	20.7262 mL
20 mM	0.2073 mL	1.0363 mL	2.0726 mL	10.3631 mL
50 mM	0.0829 mL	0.4145 mL	0.8290 mL	4.1452 mL
100 mM	0.0415 mL	0.2073 mL	0.4145 mL	2.0726 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc