store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
JQKD82 is a selective inhibitor of KDM5 and increases H3K4me3. JQKD82 can be used in studies about the treatment of multiple myeloma.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | Inquiry | $ 137.00 | |
5 mg | Inquiry | $ 617.00 | |
10 mg | Inquiry | $ 995.00 | |
25 mg | Inquiry | Inquiry | |
50 mg | Inquiry | Inquiry |
Description | JQKD82 is a selective inhibitor of KDM5 and increases H3K4me3. JQKD82 can be used in studies about the treatment of multiple myeloma. |
In vitro | In MM.1S and MOLP-8 cells, JQKD82 (1 μM) induces G1 cell cycle arrest. JQKD82 (0.3 μM) increases global H3K4me3 levels in MM.1S cells. JQKD82 (0.1-10 μM) inhibits the growth of MM.1S cells in a dose- and time-dependent manner (IC50 = 0.42 μM)[1]. |
In vivo | In female NSG mice bearing MOLP-8 TurboGFP-Luc cells, JQKD82 (50 and 75 mg/kg; i.p.) significantly reduces tumor burden. JQKD82 increases the level of H3K4me3 and significantly reduces MYC immuno-staining in vivo[1]. |
Synonyms | JADA82, PCK82, JQKD82 |
Molecular Weight | 500.63 |
Formula | C27H40N4O5 |
CAS No. | 2410512-38-6 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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JQKD82 2410512-38-6 Chromatin/Epigenetic Histone Demethylase JADA82 JQKD 82 PCK-82 JADA-82 JADA 82 JQKD-82 PCK82 PCK 82 inhibitor inhibit