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H-Glu-OtBu

Name: H-Glu-OtBu
Brand: TargetMol
SKU: T64757
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T64757Cas No. 45120-30-7

H-Glu-OtBu serves as both a non-cleavable antibody-drug conjugate (ADC) linker for ADC synthesis and an alkyl chain-based PROTAC linker for PROTAC preparation.

H-Glu-OtBu

🥰Excellent

Purity: 99.79%

Catalog No. T64757Cas No. 45120-30-7

H-Glu-OtBu serves as both a non-cleavable antibody-drug conjugate (ADC) linker for ADC synthesis and an alkyl chain-based PROTAC linker for PROTAC preparation.

Pack Size	Price	Availability	Quantity
2 g	$30	In Stock

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Batch Information

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Purity:99.79%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description

H-Glu-OtBu serves as both a non-cleavable antibody-drug conjugate (ADC) linker for ADC synthesis and an alkyl chain-based PROTAC linker for PROTAC preparation.

Chemical Properties

Molecular Weight	203.24
Formula	C₉H₁₇NO₄
Cas No.	45120-30-7
Smiles	C([C@H](CCC(O)=O)N)(OC(C)(C)C)=O

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 8 mg/mL (39.36 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.9203 mL	24.6015 mL	49.2029 mL	246.0146 mL
5 mM	0.9841 mL	4.9203 mL	9.8406 mL	49.2029 mL
10 mM	0.4920 mL	2.4601 mL	4.9203 mL	24.6015 mL
20 mM	0.2460 mL	1.2301 mL	2.4601 mL	12.3007 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc