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Inosine-5'-diphosphoric acid disodium salt (Synonyms: Inosine-5'-diphosphoric acid disodium, Inosine-5'-diphosp...)

Name: Inosine-5'-diphosphoric acid disodium salt
Brand: TargetMol
SKU: TSW-01086
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. TSW-01086 Copy Product Info

Purity: 99.93%

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Inosine-5'-diphosphoric acid disodium salt, as a decoy substrate for NM23-H2, exhibits excellent binding ability at the GDP-binding site of NM23-H2 with a dissociation constant (KD) of 5.0 μM. It can inhibit c-MYC transcription by disrupting the interaction between NM23-H2-Pu27-GQ, thereby inducing apoptosis and G2/M cell cycle arrest without affecting the kinase activity mediated by NM23-H2. Inosine-5'-diphosphoric acid disodium salt also possesses anti-hypoxic, antihypertensive, and antiarrhythmic activities, protects organisms from γ-radiation damage, and can be used in research on cancers such as Burkitt lymphoma and cardiovascular diseases.

Inosine-5'-diphosphoric acid disodium salt

Copy Product Info

🥰Excellent

Catalog No. TSW-01086

Synonyms Inosine-5'-diphosphoric acid disodium, Inosine-5'-diphosphate disodium, IDP disodium

Inosine-5'-diphosphoric acid disodium salt

Cas No. 54735-61-4

Pack Size	Price	USA Stock	Global Stock	Quantity
1 g	$29	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.93%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Inosine-5'-diphosphoric acid disodium salt, as a decoy substrate for NM23-H2, exhibits excellent binding ability at the GDP-binding site of NM23-H2 with a dissociation constant (KD) of 5.0 μM. It can inhibit c-MYC transcription by disrupting the interaction between NM23-H2-Pu27-GQ, thereby inducing apoptosis and G2/M cell cycle arrest without affecting the kinase activity mediated by NM23-H2. Inosine-5'-diphosphoric acid disodium salt also possesses anti-hypoxic, antihypertensive, and antiarrhythmic activities, protects organisms from γ-radiation damage, and can be used in research on cancers such as Burkitt lymphoma and cardiovascular diseases.
Targets&IC50	NM23-H2:5.0 μM (Kd)
In vitro	Inosine-5'-diphosphoric acid disodium salt can serve as a decoy substrate for NM23‑H2, binding to its GDP-binding site with a dissociation constant (Kd) of 5.0 μM. It can interfere with the interaction between NM23‑H2 and the c‑MYC G-quadruplex (Pu27‑GQ), and enhance the inhibitory effect of Pu27‑GQ ligands on c‑MYC transcription, thereby inducing cell apoptosis and G2/M phase cycle arrest without affecting the intrinsic kinase activity of NM23‑H2. Inosine‑5'‑diphosphate disodium also exhibits biological activities such as anti-hypoxia, anti-hyperthermia and anti-arrhythmia, can reduce the damage to the body caused by γ-rays, and has important application value in the related research of malignant tumors such as Burkitt's lymphoma and cardiovascular diseases [1][2][3].
Synonyms	Inosine-5'-diphosphoric acid disodium, Inosine-5'-diphosphate disodium, IDP disodium

Chemical Properties

Molecular Weight	472.15
Formula	C₁₀H₁₂N₄Na₂O₁₁P₂
Cas No.	54735-61-4
Smiles	O[C@H]1[C@H](N2C3=C(N=C2)C(N=CN3)=O)O[C@H](COP(OP([O-])([O-])=O)(O)=O)[C@H]1O.[Na+].[Na+]

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 140 mg/mL (296.52 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	2.1180 mL	10.5899 mL	21.1797 mL	105.8985 mL
5 mM	0.4236 mL	2.1180 mL	4.2359 mL	21.1797 mL
10 mM	0.2118 mL	1.0590 mL	2.1180 mL	10.5899 mL
20 mM	0.1059 mL	0.5295 mL	1.0590 mL	5.2949 mL
50 mM	0.0424 mL	0.2118 mL	0.4236 mL	2.1180 mL
100 mM	0.0212 mL	0.1059 mL	0.2118 mL	1.0590 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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