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Methotrexate α-tert-butyl ester
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Catalog No. T72123Cas No. 79640-70-3
Methotrexate α-tert-butyl ester is a protected analog of the antineoplastic and immunosuppressive drug methotrexate (MTX), in which the β-carboxyl group of the L-glutamate moiety is esterified with a tert-butyl group. Methotrexate α-tert-butyl ester is primarily used in chemical synthesis and prodrug development studies.
Methotrexate α-tert-butyl ester
😃Good
Catalog No. T72123Cas No. 79640-70-3
Methotrexate α-tert-butyl ester is a protected analog of the antineoplastic and immunosuppressive drug methotrexate (MTX), in which the β-carboxyl group of the L-glutamate moiety is esterified with a tert-butyl group. Methotrexate α-tert-butyl ester is primarily used in chemical synthesis and prodrug development studies.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $93 | - | In Stock | |
| 5 mg | $228 | - | In Stock | |
| 10 mg | $372 | - | In Stock | |
| 25 mg | $613 | - | In Stock | |
| 50 mg | $869 | - | In Stock | |
| 100 mg | $1,170 | - | In Stock | |
| 200 mg | $1,570 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Methotrexate α-tert-butyl ester is a protected analog of the antineoplastic and immunosuppressive drug methotrexate (MTX), in which the β-carboxyl group of the L-glutamate moiety is esterified with a tert-butyl group. Methotrexate α-tert-butyl ester is primarily used in chemical synthesis and prodrug development studies. |
| In vitro | MTX-PVG exhibits activity against HT1080 cells, the OtBu-MTX-PVG derivative(Methotrexate α-tert-butyl ester) is less active, indicating that protecting the α-carboxyl group of MTX Results in decreased in vitro activity.[1] |
| In vivo | In HT1080 tumor-bearing mice, Methotrexate α-tert-butyl ester significantly inhibits tumor growth. This finding suggests that protecting the α-carboxyl group of methotrexate can enhance the circulatory half-life and minimize liver accumulation for similar dendrimer conjugates without compromising their in vivo antitumor efficacy.[1] |
| Molecular Weight | 510.555 |
| Formula | C24H30N8O5 |
| Cas No. | 79640-70-3 |
| Smiles | NC=1C2=C(N=C(N)N1)N=CC(CN(C)C3=CC=C(C(N[C@H](C(OC(C)(C)C)=O)CCC(O)=O)=O)C=C3)=N2 |
| Color | Yellow |
| Appearance | Solid |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80.00 mg/mL (156.69 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSO (stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyThe above example illustrates how to use "In Vivo Formulation Calculator" and does not represent a recommended formulation for any specific compound. Please select an appropriate dissolution method based on your experimental animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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