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Pixantrone dimaleate

Name: Pixantrone dimaleate
Brand: TargetMol
SKU: T2394
Price: 47 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2394Cas No. 144675-97-8

Alias Pixantrone dimaleate, BBR-2778, BBR 2778 dimaleate

Pixantrone dimaleate (Pixantrone Maleate) (BBR 2778 dimaleate) is an experimental antineoplastic drug.

Pixantrone dimaleate

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Purity: 99.11%

Catalog No. T2394Alias Pixantrone dimaleate, BBR-2778, BBR 2778 dimaleateCas No. 144675-97-8

Pixantrone dimaleate (Pixantrone Maleate) (BBR 2778 dimaleate) is an experimental antineoplastic drug.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$47	In Stock	In Stock
10 mg	$72	In Stock	In Stock
25 mg	$133	In Stock	In Stock
50 mg	$228	In Stock	In Stock
100 mg	$347	In Stock	In Stock
500 mg	$825	-	In Stock
1 mL x 10 mM (in DMSO)	$59	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.11%

Appearance:Solid

Color:Blue to Black

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Pixantrone dimaleate (Pixantrone Maleate) (BBR 2778 dimaleate) is an experimental antineoplastic drug.
Kinase Assay	Recombinant RT enzymes are expressed, purified, and assessed for inhibition by Efavirenz (L-743726). Ki and Kii values are determined for each enzyme tested. The wild-type RT exhibited exclusively noncompetitive inhibition kinetics (data not shown), and, therefore, the Ki and Kii values are identical. Pure noncompetitive inhibition is not assumed for the mutant enzymes, and, hence, the values of both Ki and Kii are obtained from the linear mixed-type inhibition equation. The two- to threefold differences between the Ki and Kii values probably reflect a small contribution of competitive inhibition with the mutant RTs[1].
Synonyms	Pixantrone dimaleate, BBR-2778, BBR 2778 dimaleate

Chemical Properties

Molecular Weight	557.21
Formula	C₂₅H₂₇N₅O₁₀
Cas No.	144675-97-8
Smiles	OC(=O)\C=C/C(O)=O.OC(=O)\C=C/C(O)=O.NCCNc1ccc(NCCN)c2C(=O)c3cnccc3C(=O)c12
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 91 mg/mL (163.31 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 1 mg/mL (1.79 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7947 mL	8.9733 mL	17.9466 mL	89.7328 mL
5 mM	0.3589 mL	1.7947 mL	3.5893 mL	17.9466 mL
10 mM	0.1795 mL	0.8973 mL	1.7947 mL	8.9733 mL
20 mM	0.0897 mL	0.4487 mL	0.8973 mL	4.4866 mL
50 mM	0.0359 mL	0.1795 mL	0.3589 mL	1.7947 mL
100 mM	0.0179 mL	0.0897 mL	0.1795 mL	0.8973 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc