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Pixantrone dimaleate

Name: Pixantrone dimaleate
Brand: TargetMol
SKU: T2394
Price: 47 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T2394Cas No. 144675-97-8

Alias Pixantrone dimaleate, BBR-2778, BBR 2778 dimaleate

Pixantrone dimaleate (Pixantrone Maleate) (BBR 2778 dimaleate) is an experimental antineoplastic drug.

Pixantrone dimaleate

🥰Excellent

Purity: 99.11%

Catalog No. T2394Alias Pixantrone dimaleate, BBR-2778, BBR 2778 dimaleateCas No. 144675-97-8

Pixantrone dimaleate (Pixantrone Maleate) (BBR 2778 dimaleate) is an experimental antineoplastic drug.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$47	In Stock	In Stock
10 mg	$72	In Stock	In Stock
25 mg	$133	In Stock	In Stock
50 mg	$228	In Stock	In Stock
100 mg	$347	In Stock	In Stock
500 mg	$825	-	In Stock
1 mL x 10 mM (in DMSO)	$59	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.11%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Pixantrone dimaleate (Pixantrone Maleate) (BBR 2778 dimaleate) is an experimental antineoplastic drug.
Kinase Assay	Recombinant RT enzymes are expressed, purified, and assessed for inhibition by Efavirenz (L-743726). Ki and Kii values are determined for each enzyme tested. The wild-type RT exhibited exclusively noncompetitive inhibition kinetics (data not shown), and, therefore, the Ki and Kii values are identical. Pure noncompetitive inhibition is not assumed for the mutant enzymes, and, hence, the values of both Ki and Kii are obtained from the linear mixed-type inhibition equation. The two- to threefold differences between the Ki and Kii values probably reflect a small contribution of competitive inhibition with the mutant RTs[1].
Synonyms	Pixantrone dimaleate, BBR-2778, BBR 2778 dimaleate

Chemical Properties

Molecular Weight	557.21
Formula	C₂₅H₂₇N₅O₁₀
Cas No.	144675-97-8
Smiles	OC(=O)\C=C/C(O)=O.OC(=O)\C=C/C(O)=O.NCCNc1ccc(NCCN)c2C(=O)c3cnccc3C(=O)c12
Relative Density.	no data available
Color	Blue
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 91 mg/mL (163.31 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 1 mg/mL (1.79 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7947 mL	8.9733 mL	17.9466 mL	89.7328 mL
5 mM	0.3589 mL	1.7947 mL	3.5893 mL	17.9466 mL
10 mM	0.1795 mL	0.8973 mL	1.7947 mL	8.9733 mL
20 mM	0.0897 mL	0.4487 mL	0.8973 mL	4.4866 mL
50 mM	0.0359 mL	0.1795 mL	0.3589 mL	1.7947 mL
100 mM	0.0179 mL	0.0897 mL	0.1795 mL	0.8973 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc