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Astringin

Name: Astringin
Brand: TargetMol
SKU: TN1412
Price: 56 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN1412Cas No. 29884-49-9

Alias trans-Astringin

Astringin (trans-Astringin) is an orally active natural flavonoid that mitigates oxidative stress and inflammatory responses by inhibiting the PI3K/AKT/NF-κB pathway. It also modulates TLR4/MyD88, HMGB1/RAGE, and NF-κB pathways to counteract chromium-induced nephrotoxicity, whilst inhibiting ferroptosis.

Astringin

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Purity: 99.87%

Catalog No. TN1412Alias trans-AstringinCas No. 29884-49-9

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$56	-	In Stock
5 mg	$198	-	In Stock
10 mg	$363	-	In Stock
25 mg	$589	-	In Stock
50 mg	$855	-	In Stock
100 mg	$1,150	-	In Stock
1 mL x 10 mM (in DMSO)	$226	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.87%

Appearance:Solid

Color:Yellow

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Astringin (trans-Astringin) is an orally active natural flavonoid that mitigates oxidative stress and inflammatory responses by inhibiting the PI3K/AKT/NF-κB pathway. It also modulates TLR4/MyD88, HMGB1/RAGE, and NF-κB pathways to counteract chromium-induced nephrotoxicity, whilst inhibiting ferroptosis.
In vitro	In LPS-stimulated A549 cells, Astringin (0-75 µg/mL, 0-26 hours) enhanced cell viability, inhibited apoptosis, blocked the increase in ROS and MDA levels, and reduced the production of inflammatory factors such as TNF-α, IL-1β, and IL-6. Its mechanism of action is associated with the inhibition of the PI3K/AKT/NF-κB signaling pathway [1]. Astringin (1-100 µM) acted on Erastin-treated bone marrow mesenchymal stem cells and effectively inhibited lipid peroxidation [2].
In vivo	After 4 weeks of intragastric administration, Astringin (10 mg/kg) effectively alleviated chromium-induced oxidative stress, inflammation, apoptosis, and renal tissue damage in rats [3].
Synonyms	trans-Astringin

Chemical Properties

Molecular Weight	406.38
Formula	C₂₀H₂₂O₉
Cas No.	29884-49-9
Smiles	O([C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C2=CC(/C=C/C3=CC(O)=C(O)C=C3)=CC(O)=C2
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (196.86 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 1 mg/mL (2.46 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4608 mL	12.3038 mL	24.6075 mL	123.0376 mL
5 mM	0.4922 mL	2.4608 mL	4.9215 mL	24.6075 mL
10 mM	0.2461 mL	1.2304 mL	2.4608 mL	12.3038 mL
20 mM	0.1230 mL	0.6152 mL	1.2304 mL	6.1519 mL
50 mM	0.0492 mL	0.2461 mL	0.4922 mL	2.4608 mL
100 mM	0.0246 mL	0.1230 mL	0.2461 mL	1.2304 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc