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(20607)
Research Areas Research AreasCerebrovascular system
Cerebrovascular diseases involve pathological conditions affecting cerebral blood vessels and circulation, with stroke being the most prominent manifestation. Hypertension is the principal modifiable risk factor, contributing to vascular remodeling and atherosclerosis. These disorders may also result in vascular cognitive impairment and dementia. Research efforts focused on neurovascular coupling, ischemia-reperfusion injury, and neuroprotection are vital for improving acute management and long-term neurological outcomes.
Deferoxamine
Cited
Desferrioxamine B, Deferoxamine B
T12435870-51-9
Deferoxamine (Desferrioxamine B) is an iron chelator. Deferoxamine can be used to reduce the accumulation and deposition of iron in tissues. Deferoxamine can improve neurological dysfunction by inhibiting ferroptosis and neuroinflammation after traumatic brain injury. It has antioxidant, anti-proliferation and anti-tumor activities, and can induce the production of HIF-1α, apoptosis and autophagy in cancer cells. It can be used to treat acute iron toxicity and COVID-19 related diseases.
- $58
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CitedHeparin Cited
Dalteparin, Certoparin, Bemiparin, Adomiparin
T206549005-49-6
Heparin (Adomiparin) is a mucopolysaccharide sulfate often used as an anticoagulant in clinical medicine.Heparin has shown partial anti-inflammatory activity in in vivo experiments.
- $66
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CitedClazosentan
VML 588, Ro 61-1790, AXV-034343
T64084180384-56-9In house
Clazosentan (Ro 61-1790) is a selective antagonist of the endothelin A receptor (ETAreceptor) that inhibits ET-1-mediated vasoconstriction, preventing cerebral vasospasm and vasospasm-associated cerebral infarction.
- $68
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Praliciguat
IW-1973
T165691628730-49-3
Praliciguat (IW-1973) stimulates sGC in HEK-293 cells (EC50: 197 nM). Praliciguat is an effective and orally active soluble guanylate cyclase stimulator. It also enhances NO signaling and acts as a vasodilator.
- $153
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Laropiprant
MK-0524
T15712571170-77-9
Laropiprant (MK-0524) is a potent and selective antagonist of prostaglandin D2 (PGD2) receptor (DP) such as and DP/DP1 receptor(Ki = 0.57 nM) and TP Receptor(Ki = 2.95 nM).
- $32
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AZD 4017
T143881024033-43-9
AZD 4017 is an inhibitor of 11β-Hydroxysteroid Dehydrogenase Type 1(11β-HSD1) (IC50: 7 nM).
- $67
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Citicoline Cited
cytidine diphosphate-choline, cytidine 5'-diphosphocholine, Citicholine, CDP-Choline
T0136987-78-0
Citicoline (CDP-Choline) is an intermediate in the synthesis of phosphatidylcholine, a component of cell membranes. Citicoline exerts neuroprotective effects.
- $30
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CitedPhalloidin
T1951217466-45-4
Phalloidin, a bicyclic heptapeptide found in Gooseberry, is involved in F-actin staining. Phalloidin is a compound that irreversibly polymerizes actin into microfilaments.Phalloidin interferes with cell motility and growth, and can be used to label cerebral blood vessels.
- $599
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PLGA
poly(lactic-co-glycolic acid), PLGA (50:50)
T1952134346-01-5
PLGA (poly(lactic-co-glycolic acid)) is be used to fabricate devices for drug delivery and tissue engineering applications.
- $33
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Elezanumab
AE12-1Y-QL, ABT-555
T768631791416-49-3
Elezanumab(ABT-555) is a potent human anti-RGMa monoclonal antibody.Elezanumab exerts its inhibitory effect on RGMa-mediated BMP signaling through the SMAD1/5/8 pathway, with an IC50 of approximately 97 pM.Elezanumab promotes neuroregeneration, neuroprotection, and neural restoration in models of neuronal injury and demyelination. Elezanumab promotes the growth of corticospinal axons into spinal gray matter and enhances serotonergic innervation in the ventral horn, forming synaptic connections in the caudal part of cervical lesions.
- $247
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NP10679
T734472914889-88-4In house
NP10679 is an orally available, selective, brain-penetrating, potent, and pH-sensitive N-methyl-D-aspartate (NMDA) receptor inhibitor of the GluN2B subunit.NP10679 inhibits histamine H1, hERG channels, and CYP enzymes, and may be useful in the study of epilepsy and ischemic stroke.
- $293
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Ifenprodil
RC61-91, RC-61-91, RC 61-91, RC 6191
T1186L23210-56-2
Ifenprodil (RC61-91) is an inhibitor of the NMDA receptor, specifically of GluN1 (glycine-binding NMDA receptor subunit 1) and GluN2B (glutamate-binding NMDA receptor subunit 2) subunits. Additionally, Ifenprodil inhibits GIRK channels and interacts with alpha1 adrenergic, serotonin, and sigma receptors.
- $61
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Troxerutin Cited
Trihydroxyethylrutin
T07727085-55-4
Troxerutin (Trihydroxyethylrutin), a natural bioflavonoid, is isolated from Sophora japonica. It has many benefits and medicinal properties.
- $29
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CitedPropentofylline
Propentophylline, Karsivan, HWA-285, HWA285, HWA 285, Hextol
T1981255242-55-2In house
Propentofylline (Hextol) is a methylxanthine derivative with neuroprotective, antiproliferative, and anti-inflammatory activity and enhanced synaptic adenosine signaling, which may be useful in the study of Alzheimer's disease, vascular dementia, cognitive impairment, dementia, and chronic pain.
- $39
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Repinotan
BAY x 3702 free base
T61934144980-29-0In house
Repinotan (BAY x 3702 free base) is an orally active, selective 5-HT1A receptor agonist that crosses the blood-brain barrier (BBB), exhibits neuroprotective activity, counteracts morphine-induced depression of ventilation in anesthetized rats, and may be used in studies of acute ischemic stroke and traumatic brain injury.
- $293
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Nelonemdaz
Salfaprodil free base, Neu2000
T16286640290-67-1In house
Nelonemdaz (Neu2000) is an NMDA receptor antagonist with antioxidant activity and neuroprotective activity used in the study of cerebral infarction reperfusion injury and acute ischemic stroke.
- $38
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Dipyridamole Cited
Persantin, NSC-515776, Dypyridamole, Dipyudamine, Dipyridamol
T161858-32-2
Dipyridamole (Persantin) is a Platelet Aggregation Inhibitor. The physiologic effect of dipyridamole is by means of Decreased Platelet Aggregation.
- $38
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CitedFanapanel
ZK200775, ZK 200775, MPQX
T13405L161605-73-8
Fanapanel (ZK200775) is a quinoxalinedione derivative and potent competitive antagonist of AMPAR for cerebrovascular-related studies.
- $69
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Ligustrazine Cited
Tetramethylpyrazine
T27221124-11-4
Ligustrazine (Tetramethylpyrazine), a natural compound isolated from Chinese herbal medicine Ligusticum wallichii (Chuan Xiong) shows anti-inflammation, antioxidant, antiplatelet, and antiapoptosis activities.
- $42
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CitedPropyl gallate
Tenox PG, n-Propyl gallate, Gallic acid propyl esterZ
T3S1866121-79-9
Propyl gallate (Gallic acid propyl esterZ) is an antioxidant used in foods especially animal fats and vegetable oils, also in a wide variety of cosmetics and beauty care products.
- $48
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Vincamine
Perval, Oxybral, Novicet, Equipur, Devincan, Angiopac
T12861617-90-9
Vincamine (Perval) is a major alkaloid of Vinca minor L., Apocynaceae. It has been used therapeutically as a vasodilator and antihypertensive agent, particularly in cerebrovascular disorders.
- $40
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Protirelin Acetate
TSH-RF Acetate, TRH Acetate, TRF Acetate
TP1022120876-23-5
Protirelin Acetate (TRH Acetate) is a thyrotropin-releasing hormone, stimulating the release of thyrotropin and prolactin from the anterior pituitary.
- $40
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Isoxsuprine hydrochloride
Isolait, Duvadilan
T0324579-56-6
Isoxsuprine hydrochloride (Isolait) is a beta-adrenergic agonist that causes direct relaxation of uterine and vascular smooth muscle.
- $30
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Aptiganel hydrochloride
CNS 1102, Cerestat
T38068137160-11-3
Aptiganel hydrochloride（Cerestat） is the salt form of Aptiganel.Aptiganel is a non-competitive NMDA antagonist with neuroprotective effects used in the treatment of stroke and focal cerebral ischemia.
- $30
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