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PRGL493

🥰Excellent
Catalog No. T35666Cas No. 2479378-45-3

PRGL493 is an inhibitor of long-chain acyl-CoA synthetase 4 (ACSL4).1It inhibits formation of arachidonoyl-CoA (AA-CoA) from arachidonic acid in, as well as the proliferation and migration of, PC3 and MDA-MB-231 cancer cells when used at a concentration of 50 μM. PRGL493 (5 μM) reduces production of progesterone induced by 8-Br-cyclic AMP (8-Br-cAMP) in MA-10 Leydig tumor cells. It inhibits tumor growth in a PC3 mouse xenograft model when administered at a dose of 0.25 mg/kg.

PRGL493

PRGL493

🥰Excellent
Purity: 99.11%
Catalog No. T35666Cas No. 2479378-45-3
PRGL493 is an inhibitor of long-chain acyl-CoA synthetase 4 (ACSL4).1It inhibits formation of arachidonoyl-CoA (AA-CoA) from arachidonic acid in, as well as the proliferation and migration of, PC3 and MDA-MB-231 cancer cells when used at a concentration of 50 μM. PRGL493 (5 μM) reduces production of progesterone induced by 8-Br-cyclic AMP (8-Br-cAMP) in MA-10 Leydig tumor cells. It inhibits tumor growth in a PC3 mouse xenograft model when administered at a dose of 0.25 mg/kg.
Pack SizePriceAvailabilityQuantity
1 mg$59In Stock
5 mg$147In Stock
10 mg$239In Stock
25 mg$392In Stock
50 mg$588In Stock
100 mg$838In Stock
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Purity:99.11%
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COA HPLC HNMR

Product Introduction

Bioactivity
Description
PRGL493 is an inhibitor of long-chain acyl-CoA synthetase 4 (ACSL4).1It inhibits formation of arachidonoyl-CoA (AA-CoA) from arachidonic acid in, as well as the proliferation and migration of, PC3 and MDA-MB-231 cancer cells when used at a concentration of 50 μM. PRGL493 (5 μM) reduces production of progesterone induced by 8-Br-cyclic AMP (8-Br-cAMP) in MA-10 Leydig tumor cells. It inhibits tumor growth in a PC3 mouse xenograft model when administered at a dose of 0.25 mg/kg.
Chemical Properties
Molecular Weight451.48
FormulaC25H21N7O2
Cas No.2479378-45-3
SmilesCC(=O)NC1=NC(N2C(Nc3ccccc23)=N1)c1cn(nc1-c1ccc(C)o1)-c1ccccc1
Storage & Solubility Information
Storagestore at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
Chloroform: 1 mg/mL (2.21 mM), Sonication is recommended.
DMSO: 4.5 mg/mL (10.0 mM), Sonication and heating to 60℃ are recommended.
Solution Preparation Table
Chloroform/DMSO
1mg5mg10mg50mg
1 mM2.2149 mL11.0747 mL22.1494 mL110.7469 mL
DMSO
1mg5mg10mg50mg
5 mM0.4430 mL2.2149 mL4.4299 mL22.1494 mL
10 mM0.2215 mL1.1075 mL2.2149 mL11.0747 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

PRGL-493PRGL493PRGL 493long-chain acyl-CoA synthetase 4
Related Tags: buy PRGL493 | purchase PRGL493 | PRGL493 cost | order PRGL493 | PRGL493 chemical structure | PRGL493 formula | PRGL493 molecular weight
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