Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Seco-DUBA, a duocarmycin (DUBA) prodrug, possess two hydroxyl groups suitable for antibody coupling through a linker. This compound, serving as a precursor, enables the synthesis of antibody-drug conjugates (ADCs).
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1 mg | Inquiry | $ 1,289.00 | |
5 mg | Inquiry | $ 4,000.00 | |
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Description | Seco-DUBA, a duocarmycin (DUBA) prodrug, possess two hydroxyl groups suitable for antibody coupling through a linker. This compound, serving as a precursor, enables the synthesis of antibody-drug conjugates (ADCs). |
In vitro | Seco-DUBA demonstrates dose-dependent reduction in cell viability over 144 hours across concentrations ranging from 0.0001 pM to 0.01 nM in SK-BR-3 cells, proving to be as potent and efficacious as DUBA[1]. Additionally, it exhibits high sensitivity in reducing the viability of SK-BR-3 (IC 50 =0.09), SK-OV-3 (IC 50 =0.43), and SW620 (IC 50 =0.09) cells[1]. This is further corroborated by a Cell Cytotoxicity Assay conducted on the SK-BR-3 cell line within the specified concentration and incubation period, affirming the dose-dependent decrease in cell viability[1]. |
In vivo | Seco-DUBA, at a dosage of 89 µg/kg administered intravenously, is likely transformed into DUBA almost instantaneously in Wistar rats, as indicated in pharmacokinetic analysis[1]. |
Molecular Weight | 526.98 |
Formula | C29H23ClN4O4 |
CAS No. | 1227961-59-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Seco-DUBA 1227961-59-2 SecoDUBA Seco DUBA inhibitor inhibit