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Seco-DUBA

Name: Seco-DUBA
Brand: TargetMol
SKU: T38611
Price: 977 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T38611Cas No. 1227961-59-2

Alias SecoDUBA

Seco-DUBA is an anticancer DNA alkylating agent and prodrug of DUBA, which can be used as a cytotoxic antibody-drug conjugate (ADC). It has an IC50 of 18 nM against KB and 430 pM against SK-OV-3, and can be converted into DUBA with higher stability and activity in vivo.

Seco-DUBA

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Purity: 99.81%

Catalog No. T38611Alias SecoDUBACas No. 1227961-59-2

Pack Size	Price	Availability
1 mg	$977	In Stock
5 mg	$2,190	In Stock
10 mg	$3,190	In Stock
25 mg	$5,750	In Stock

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Purity:99.81%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Seco-DUBA is an anticancer DNA alkylating agent and prodrug of DUBA, which can be used as a cytotoxic antibody-drug conjugate (ADC). It has an IC50 of 18 nM against KB and 430 pM against SK-OV-3, and can be converted into DUBA with higher stability and activity in vivo.
In vitro	Method: SK-BR-3 cells were exposed to various concentrations of Seco-DUBA (ranging from 0.0001 pM to 0.01 nM) for 144 hours to evaluate its cytotoxic effects. Result: Seco-DUBA treatment led to a dose-dependent reduction in SK-BR-3 cell viability.[1]
In vivo	Method: Pharmacokinetic analysis was conducted in Wistar rats. Seco-DUBA was administered via intravenous injection at a dose of 89 μg/kg. Result: Seco-DUBA was likely converted to DUBA almost instantaneously in vivo. [1]
Synonyms	SecoDUBA

Chemical Properties

Molecular Weight	526.97
Formula	C₂₉H₂₃ClN₄O₄
Cas No.	1227961-59-2
Smiles	C(Cl)[C@H]1C2=C(N(C(=O)C=3N=C4N(C3)C=C(NC(=O)C5=CC=C(O)C=C5)C=C4)C1)C=C(O)C=6C2=C(C)C=CC6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80.00 mg/mL (151.81 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8976 mL	9.4882 mL	18.9764 mL	94.8821 mL
5 mM	0.3795 mL	1.8976 mL	3.7953 mL	18.9764 mL
10 mM	0.1898 mL	0.9488 mL	1.8976 mL	9.4882 mL
20 mM	0.0949 mL	0.4744 mL	0.9488 mL	4.7441 mL
50 mM	0.0380 mL	0.1898 mL	0.3795 mL	1.8976 mL
100 mM	0.0190 mL	0.0949 mL	0.1898 mL	0.9488 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc