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Seco-DUBA

Name: Seco-DUBA
Brand: TargetMol
SKU: T38611
Price: 977 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T38611Cas No. 1227961-59-2

Alias SecoDUBA

Seco-DUBA is an anticancer DNA alkylating agent and prodrug of DUBA, which can be used as a cytotoxic antibody-drug conjugate (ADC). It has an IC50 of 18 nM against KB and 430 pM against SK-OV-3, and can be converted into DUBA with higher stability and activity in vivo.

Seco-DUBA

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Purity: 99.81%

Catalog No. T38611Alias SecoDUBACas No. 1227961-59-2

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$977	In Stock	In Stock
5 mg	$2,190	-	In Stock
10 mg	$3,190	-	In Stock
25 mg	$5,750	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.81%

Appearance:Solid

Color:White to Yellow

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Seco-DUBA is an anticancer DNA alkylating agent and prodrug of DUBA, which can be used as a cytotoxic antibody-drug conjugate (ADC). It has an IC50 of 18 nM against KB and 430 pM against SK-OV-3, and can be converted into DUBA with higher stability and activity in vivo.
In vitro	Method: SK-BR-3 cells were exposed to various concentrations of Seco-DUBA (ranging from 0.0001 pM to 0.01 nM) for 144 hours to evaluate its cytotoxic effects. Result: Seco-DUBA treatment led to a dose-dependent reduction in SK-BR-3 cell viability.[1]
In vivo	Method: Pharmacokinetic analysis was conducted in Wistar rats. Seco-DUBA was administered via intravenous injection at a dose of 89 μg/kg. Result: Seco-DUBA was likely converted to DUBA almost instantaneously in vivo. [1]
Synonyms	SecoDUBA

Chemical Properties

Molecular Weight	526.97
Formula	C₂₉H₂₃ClN₄O₄
Cas No.	1227961-59-2
Smiles	C(Cl)[C@H]1C2=C(N(C(=O)C=3N=C4N(C3)C=C(NC(=O)C5=CC=C(O)C=C5)C=C4)C1)C=C(O)C=6C2=C(C)C=CC6

Storage & Solubility Information

Storage

store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (151.81 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8976 mL	9.4882 mL	18.9764 mL	94.8821 mL
5 mM	0.3795 mL	1.8976 mL	3.7953 mL	18.9764 mL
10 mM	0.1898 mL	0.9488 mL	1.8976 mL	9.4882 mL
20 mM	0.0949 mL	0.4744 mL	0.9488 mL	4.7441 mL
50 mM	0.0380 mL	0.1898 mL	0.3795 mL	1.8976 mL
100 mM	0.0190 mL	0.0949 mL	0.1898 mL	0.9488 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc