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Seco-DUBA
🥰Excellent
Catalog No. T38611Cas No. 1227961-59-2
Alias SecoDUBA
Seco-DUBA is an anticancer DNA alkylating agent and prodrug of DUBA, which can be used as a cytotoxic antibody-drug conjugate (ADC). It has an IC50 of 18 nM against KB and 430 pM against SK-OV-3, and can be converted into DUBA with higher stability and activity in vivo.
Seco-DUBA
🥰Excellent
Purity: 99.81%
Catalog No. T38611Alias SecoDUBACas No. 1227961-59-2
Seco-DUBA is an anticancer DNA alkylating agent and prodrug of DUBA, which can be used as a cytotoxic antibody-drug conjugate (ADC). It has an IC50 of 18 nM against KB and 430 pM against SK-OV-3, and can be converted into DUBA with higher stability and activity in vivo.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $977 | In Stock | |
| 5 mg | $2,190 | In Stock | |
| 10 mg | $3,190 | In Stock | |
| 25 mg | $5,750 | In Stock |
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Purity:99.81%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Seco-DUBA is an anticancer DNA alkylating agent and prodrug of DUBA, which can be used as a cytotoxic antibody-drug conjugate (ADC). It has an IC50 of 18 nM against KB and 430 pM against SK-OV-3, and can be converted into DUBA with higher stability and activity in vivo. |
| In vitro | Method: SK-BR-3 cells were exposed to various concentrations of Seco-DUBA (ranging from 0.0001 pM to 0.01 nM) for 144 hours to evaluate its cytotoxic effects. Result: Seco-DUBA treatment led to a dose-dependent reduction in SK-BR-3 cell viability.[1] |
| In vivo | Method: Pharmacokinetic analysis was conducted in Wistar rats. Seco-DUBA was administered via intravenous injection at a dose of 89 μg/kg. Result: Seco-DUBA was likely converted to DUBA almost instantaneously in vivo. [1] |
| Synonyms | SecoDUBA |
| Molecular Weight | 526.97 |
| Formula | C29H23ClN4O4 |
| Cas No. | 1227961-59-2 |
| Smiles | C(Cl)[C@H]1C2=C(N(C(=O)C=3N=C4N(C3)C=C(NC(=O)C5=CC=C(O)C=C5)C=C4)C1)C=C(O)C=6C2=C(C)C=CC6 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80.00 mg/mL (151.81 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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