Capsanthin

Name: Capsanthin
Brand: TargetMol
SKU: TN3588
Rating: 4.5 (1 reviews)

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Capsanthin, an active constituent of chili peppers, functions as a TRPV1 agonist. Capsanthin induces nociceptive responses through receptor binding interactions. Capsanthin additionally demonstrates analgesic effects in neurological disorder-related studies and exhibits antioxidant, anti-inflammatory, and anticarcinogenic activities. Capsanthin is extensively utilized in sensory neuroscience, pain signaling, inflammation biology, and ion channel pharmacology research.

Cas No. 465-42-9

Pack Size	Price	USA Stock	Global Stock	Quantity
500 µg	$2,890	35 days	35 days
1 mg	$4,330	35 days	35 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	Capsanthin, an active constituent of chili peppers, functions as a TRPV1 agonist. Capsanthin induces nociceptive responses through receptor binding interactions. Capsanthin additionally demonstrates analgesic effects in neurological disorder-related studies and exhibits antioxidant, anti-inflammatory, and anticarcinogenic activities. Capsanthin is extensively utilized in sensory neuroscience, pain signaling, inflammation biology, and ion channel pharmacology research.
In vitro	Capsanthin (10 μM, 2d) inhibits adipogenesis (IC50=2.5 μM) in 3T3-L1 preadipocytes during adipogenesis[1]. Capsanthin (5-200 μM, 2d) induces the activation of p-AMPK in 3T3-L1 cell line with the dose dependently increased detected by WB. [1]
In vivo	Capsanthin (high fat diet+1 μmol/5 μmol/10 μmol; p.o.; 14d) enhances Female C57BL/6C mice’s spontaneous locomotive activities with dose dependency and continuously progressing weight loss. [1]

Chemical Properties

Molecular Weight	584.87
Formula	C₄₀H₅₆O₃
Cas No.	465-42-9
Smiles	C(/C=C/C(=C/C=C/C(=C/C=C/C=C(/C=C/C=C(/C=C/C=1C(C)(C)C[C@H](O)CC1C)\C)\C)/C)/C)(=O)[C@@]2(C)C(C)(C)C[C@H](O)C2
Relative Density.	1.012 g/cm3

Storage & Solubility Information

Storage

Store under nitrogen,Keep away from direct sunlight, Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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