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GW 583340 dihydrochloride

Name: GW 583340 dihydrochloride
Brand: TargetMol
SKU: T22827
Price: 113 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22827Cas No. 1173023-85-2

Alias GW583340 dihydrochloride

GW 583340 dihydrochloride is a potent and orally available dual EGFR/ErbB2 (epidermal growth factor receptor/tyrosine kinase) inhibitor and is capable of reversing ABCG2- and ABCB1-mediated resistance.GW 583340 dihydrochloride selectively inhibits the growth of human tumor cells overexpressing EGFR and ErbB2, selectively inhibits the growth of human tumor cells overexpressing EGFR and ErbB2, and inhibits 80% of tumor growth in a mouse xenograft model, with potential anticancer activity.

GW 583340 dihydrochloride

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Purity: 98.80%

Catalog No. T22827Alias GW583340 dihydrochlorideCas No. 1173023-85-2

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$113	-	In Stock
5 mg	$280	-	In Stock
10 mg	$417	-	In Stock
25 mg	$678	-	In Stock
50 mg	$948	-	In Stock
100 mg	$1,270	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.80%

Appearance:Solid

Color:Yellow

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	GW 583340 dihydrochloride is a potent and orally available dual EGFR/ErbB2 (epidermal growth factor receptor/tyrosine kinase) inhibitor and is capable of reversing ABCG2- and ABCB1-mediated resistance.GW 583340 dihydrochloride selectively inhibits the growth of human tumor cells overexpressing EGFR and ErbB2, selectively inhibits the growth of human tumor cells overexpressing EGFR and ErbB2, and inhibits 80% of tumor growth in a mouse xenograft model, with potential anticancer activity.
In vitro	Methods: GW 583340 dihydrochloride (5 μM) was used to treat cells overexpressing ABCG2 to investigate its effects on the accumulation of anticancer substrates of ABCB1 and ABCG2 in cells overexpressing ABCB1 and ABCG2. Results: GW 583340 dihydrochloride significantly increased the intracellular level of [3H]-MX in cells overexpressing ABCG2. GW 583340 dihydrochloride (2.5 μM) reversed ABCB1- and ABCG2-mediated MDR. [1]
Synonyms	GW583340 dihydrochloride

Chemical Properties

Molecular Weight	671.03
Formula	C₂₈H₂₇Cl₃FN₅O₃S₂
Cas No.	1173023-85-2
Smiles	O=S(C)(CCNCC1=NC(C2=CC3=C(NC4=CC=C(C(Cl)=C4)OCC5=CC(F)=CC=C5)N=CN=C3C=C2)=CS1)=O.Cl.Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (59.61 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.4902 mL	7.4512 mL	14.9025 mL	74.5123 mL
5 mM	0.2980 mL	1.4902 mL	2.9805 mL	14.9025 mL
10 mM	0.1490 mL	0.7451 mL	1.4902 mL	7.4512 mL
20 mM	0.0745 mL	0.3726 mL	0.7451 mL	3.7256 mL
50 mM	0.0298 mL	0.1490 mL	0.2980 mL	1.4902 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc