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MI-773

Name: MI-773
Brand: TargetMol
SKU: T63974
Rating: 4.5 (1 reviews)

(Synonyms: MI773, MI 773) Copy Product Info

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Synonyms: MI773, MI 773

Catalog No. T63974 Copy Product Info

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MI-773 is a potent inhibitor of MDM2-p53 protein-protein interaction (PPI), showing high binding affinity to MDM2 (Kd=8.2 nM) and antitumor activity.

Cas No. 1303607-07-9

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Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description	MI-773 is a potent inhibitor of MDM2-p53 protein-protein interaction (PPI), showing high binding affinity to MDM2 (Kd=8.2 nM) and antitumor activity.
Targets & IC50	MDM2-p53:8.2 nM (Kd)
Synonyms	MI773, MI 773

Chemical Properties

Molecular Weight	562.50
Formula	C₂₉H₃₄Cl₂FN₃O₃
Cas No.	1303607-07-9
Smiles	C(C(C)(C)C)[C@@H]1[C@]2([C@H]([C@H](C(N[C@H]3CC[C@H](O)CC3)=O)N1)C4=C(F)C(Cl)=CC=C4)C=5C(NC2=O)=CC(Cl)=CC5

Storage & Solubility Information

Storage

Store under nitrogen Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 42.40 mg/mL (75.38 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7778 mL	8.8889 mL	17.7778 mL	88.8889 mL
5 mM	0.3556 mL	1.7778 mL	3.5556 mL	17.7778 mL
10 mM	0.1778 mL	0.8889 mL	1.7778 mL	8.8889 mL
20 mM	0.0889 mL	0.4444 mL	0.8889 mL	4.4444 mL
50 mM	0.0356 mL	0.1778 mL	0.3556 mL	1.7778 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Related Tags: MI-773 chemical structure | MI-773 formula | MI-773 molecular weight