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SM4

Name: SM4
Brand: TargetMol
SKU: T28817
Price: 64 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T28817Cas No. 365542-77-4

Alias SM-4, SM 4

SM4 is a SOX18 small molecule inhibitor of HemSC vessel formation in vivo.

SM4

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Purity: 98.91%

Catalog No. T28817Alias SM-4, SM 4Cas No. 365542-77-4

SM4 is a SOX18 small molecule inhibitor of HemSC vessel formation in vivo.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$64	In Stock	In Stock
5 mg	$156	In Stock	In Stock
10 mg	$289	In Stock	In Stock
25 mg	$496	In Stock	In Stock
50 mg	$787	-	In Stock
100 mg	$1,090	6-8 weeks	6-8 weeks
1 mL x 10 mM (in DMSO)	$169	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.91%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

SM4 AI Summary

SM4 exhibits a broad spectrum of bioactivities. It shows cytotoxicity against human HepG2 and HEK293 cells with a CC50 value greater than 100,000.0 nM, as well as African green monkey COS7 cells. Additionally, it demonstrates antibacterial activity against glycopeptide-intermediate Staphylococcus aureus NRS 19, methicillin-resistant Staphylococcus aureus ATCC 43300, and Staphylococcus aureus ATCC 25923 with a minimum inhibitory concentration (MIC) greater than 128.0 µg/mL. SM4 also has competitive binding affinity to full-length mouse SOX18, inhibits SOX18 transcriptional activity, and prevents specific interactions involving SOX18 in HUVEC cells. It further inhibits multiple receptors, including adenosine, dopamine, histamine, muscarinic, and opioid receptors. Notably, SM4 exhibits antitumor activity by reducing tumor growth and vascular responses in the tumor region in mouse 4T1.2 cells implanted in BALB/c mice..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	SM4 is a SOX18 small molecule inhibitor of HemSC vessel formation in vivo.
Synonyms	SM-4, SM 4

Chemical Properties

Molecular Weight	292.33
Formula	C₁₉H₁₆O₃
Cas No.	365542-77-4
Smiles	C(CC1=CC2=C(C=C1)C=CC=C2)C3=C(C(O)=O)C(O)=CC=C3
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (205.25 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (3.42 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4208 mL	17.1040 mL	34.2079 mL	171.0396 mL
5 mM	0.6842 mL	3.4208 mL	6.8416 mL	34.2079 mL
10 mM	0.3421 mL	1.7104 mL	3.4208 mL	17.1040 mL
20 mM	0.1710 mL	0.8552 mL	1.7104 mL	8.5520 mL
50 mM	0.0684 mL	0.3421 mL	0.6842 mL	3.4208 mL
100 mM	0.0342 mL	0.1710 mL	0.3421 mL	1.7104 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

SOX18SM4

SM4

SM4

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