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STAT3-IN-18

Catalog No. T79609 CAS 2668267-41-0

STAT3-IN-18 (compound SPP), a platinum (IV) complex featuring an axial ligand from sandalwood, suppresses the JAK2-STAT3 pathway in breast cancer (BC) cells and exhibits anti-proliferative properties. It promotes apoptosis by activating caspase-3 and elevating levels of cleaved polyADP-ribose polymerase, in addition to enhancing maturation and antigen presentation in dendritic cells. Moreover, STAT3-IN-18 has demonstrated in vivo safety.

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STAT3-IN-18, CAS 2668267-41-0

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Description	STAT3-IN-18 (compound SPP), a platinum (IV) complex featuring an axial ligand from sandalwood, suppresses the JAK2-STAT3 pathway in breast cancer (BC) cells and exhibits anti-proliferative properties. It promotes apoptosis by activating caspase-3 and elevating levels of cleaved polyADP-ribose polymerase, in addition to enhancing maturation and antigen presentation in dendritic cells. Moreover, STAT3-IN-18 has demonstrated in vivo safety.
In vitro	STAT3-IN-18 at a concentration of 0.5 μM for 48 hours inhibits the phosphorylation of STAT3 and JAK2 in MDA-MB-231 cells, reduces the protein levels of Bcl-2 and COX-2, and increases the protein levels of Bak, Caspase-3, and Cleaved-PARP1 [1]. Additionally, STAT3-IN-18 at 0.5 μM for 36 hours induces cell cycle arrest at the S phase and promotes apoptosis in MDA-MB-231 cells after 48 hours of treatment.
In vivo	STAT3-IN-18, administered bi-daily at an equivalent dose of 1.5 mg Pt for a total of 18 days, inhibited STAT3 phosphorylation and suppressed tumor growth in the 4T1 xenograft mouse model. The median lethal dose (LD50) of STAT3-IN-18 was determined to be 10.45 mg/kg [1].

Molecular Weight	630.38
Formula	C18H24Cl2N2O6Pt
CAS No.	2668267-41-0

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Keywords

STAT3-IN-18 2668267-41-0 Angiogenesis Chromatin/Epigenetic JAK/STAT signaling Stem Cells JAK inhibitor inhibit

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