Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Quinacrine is a compound with multiple actions that is commonly used as an anti-protozoal agent. It has also been shown to be a highly potent autophagy inhibitor, although the dose required to achieve this effect is considerably cytotoxic (LD50 = 2.5 μM). Quinacrine analog 34 is a derivative of quinacrine that was designed with an improved cell viability profile (LD50 = 27 μM) to inhibit autophagy. At a minimum concentration of 0.5 μM, this compound has been shown to increase the protein levels of the autophagy biomarker LC3-II and to induce lysosome deacidification.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
500 μg | 35 days | $ 155.00 | |
1 mg | 35 days | $ 288.00 | |
5 mg | 35 days | $ 1,190.00 | |
10 mg | 35 days | $ 1,980.00 |
Description | Quinacrine is a compound with multiple actions that is commonly used as an anti-protozoal agent. It has also been shown to be a highly potent autophagy inhibitor, although the dose required to achieve this effect is considerably cytotoxic (LD50 = 2.5 μM). Quinacrine analog 34 is a derivative of quinacrine that was designed with an improved cell viability profile (LD50 = 27 μM) to inhibit autophagy. At a minimum concentration of 0.5 μM, this compound has been shown to increase the protein levels of the autophagy biomarker LC3-II and to induce lysosome deacidification. |
Molecular Weight | 358.91 |
Formula | C20H27ClN4 |
CAS No. | 1411646-44-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 10 mg/mL
DMSO:PBS (pH 7.2) (1:1): 0.5 mg/mL
Ethanol: 5 mg/mL
DMF: 10 mg/mL
You can also refer to dose conversion for different animals. More
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Quinacrine analog 34 1411646-44-0 inhibitor inhibit