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Nolatrexed
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Catalog No. T4228Cas No. 147149-76-6
Nolatrexed is a thymidylate synthase inhibitor with potential anticancer activity.
Nolatrexed
Copy Product Info🥰Excellent
Purity: 99.61%
Catalog No. T4228Cas No. 147149-76-6
Nolatrexed is a thymidylate synthase inhibitor with potential anticancer activity.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $35 | In Stock | In Stock | |
| 2 mg | $46 | In Stock | In Stock | |
| 5 mg | $83 | In Stock | In Stock | |
| 10 mg | $151 | In Stock | In Stock | |
| 25 mg | $252 | In Stock | In Stock | |
| 50 mg | $453 | In Stock | In Stock | |
| 100 mg | $667 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $97 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.61%
Appearance:Solid
Color:White
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Product Introduction
Nolatrexed AI Summary
Nolatrexed exhibits broad bioactivity with various mechanisms of action. It inhibits thymidylate synthase in Escherichia coli, Lactobacillus casei, and human cells with Ki values between 15.0 nM and 140.0 nM. It also inhibits the growth of mouse leukemia cells, human lymphoblastic leukemia cells, and human adenocarcinoma cells with IC50 values ranging from 810.0 nM to 3700.0 nM, exhibiting a shift in IC50 in the presence of thymidine. Additionally, it shows inhibitory effects on Histone Lysine Methyltransferase G9a with potencies of 316.2 nM and 11490.9 nM, and on the delayed death of the malarial parasite plastid with potencies of 2133.1 nM and 4775.5 nM. In Schwann cell assays, the compound exhibits potencies of 890.6 nM and 12817.8 nM and induces DNA re-replication in breast and colon cancer cells at 7499.3 nM and 23715.0 nM, respectively. It shows 1.47% inhibition of SARS-CoV-2 3CL-Pro protease at 20µM and inhibits SARS-CoV-2 induced cytotoxicity in VERO-6 cells at 10µM, with an inhibition percentage of -0.22% after 48 hours. Furthermore, Nolatrexed exhibits moderate inhibitory activity against human HDAC6 with varying inhibition percentages depending on the peptide substrate used. The compound has a calculated CLogP value of 1.83..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Nolatrexed is a thymidylate synthase inhibitor with potential anticancer activity. |
| Molecular Weight | 284.34 |
| Formula | C14H12N4OS |
| Cas No. | 147149-76-6 |
| Smiles | S(C1=C2C(=CC=C1C)NC(N)=NC2=O)C=3C=CN=CC3 |
| Relative Density. | 1.46g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 11 mg/mL (38.69 mM), Sonication is recommended.  | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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