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PSB-12379

Name: PSB-12379
Brand: TargetMol
SKU: T12569
Rating: 4.5 (1 reviews)

🥰Excellent

Catalog No. T12569Cas No. 1802226-78-3

PSB-12379 is a potent inhibitor of Ecto-5'-Nucleotidase (CD73)(Kis of 9.03 nM (rat) and 2.21 nM (human)).

PSB-12379

🥰Excellent

Catalog No. T12569Cas No. 1802226-78-3

PSB-12379 is a potent inhibitor of Ecto-5'-Nucleotidase (CD73)(Kis of 9.03 nM (rat) and 2.21 nM (human)).

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Product Introduction

Bioactivity

Description	PSB-12379 is a potent inhibitor of Ecto-5'-Nucleotidase (CD73)(Kis of 9.03 nM (rat) and 2.21 nM (human)).
Targets&IC50	Rat:9.03 nM (Ki), Ecto-5’-Nucleotidase (human):2.21 nM (human) (Ki)

Chemical Properties

Molecular Weight	515.35
Formula	C₁₈H₂₃N₅O₉P₂
Cas No.	1802226-78-3
Smiles	O[C@H]1[C@](N2C=3C(N=C2)=C(NCC4=CC=CC=C4)N=CN3)(O[C@H](COP(CP(=O)(O)O)(=O)O)[C@H]1O)[H]
Relative Density.	1.89 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 7.14 mg/mL (13.85 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	1.9404 mL	9.7021 mL	19.4043 mL	97.0214 mL
5 mM	0.3881 mL	1.9404 mL	3.8809 mL	19.4043 mL
10 mM	0.1940 mL	0.9702 mL	1.9404 mL	9.7021 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc