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GW 583340 is a potent and selective dual inhibitor of EGFR/ErbB2 tyrosine kinase with the advantage of oral dosability and antitumor effects.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $195 | In Stock | |
5 mg | $483 | In Stock | |
10 mg | $692 | In Stock | |
25 mg | $1,080 | In Stock | |
50 mg | $1,490 | In Stock | |
100 mg | $1,970 | In Stock | |
200 mg | $2,690 | In Stock |
Description | GW 583340 is a potent and selective dual inhibitor of EGFR/ErbB2 tyrosine kinase with the advantage of oral dosability and antitumor effects. |
In vitro | Methods: Intracellular accumulation of [3H]-MX, a known substrate of ABCG2, was measured in cells overexpressing ABCG2 in the presence or absence of 5 μM GW 583340. Results: GW 583340 and GW2974 significantly increased the intracellular levels of [3H]-MX in cells overexpressing ABCG2.[2] |
Alias | GW583340 |
Molecular Weight | 598.11 |
Formula | C28H25ClFN5O3S2 |
Cas No. | 388082-81-3 |
Smiles | O=S(=O)(C)CCNCC1=NC(=CS1)C=2C=CC3=NC=NC(NC4=CC=C(OCC=5C=CC=C(F)C5)C(Cl)=C4)=C3C2 |
Relative Density. | no data available |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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