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TMLZ-G46
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Catalog No. T212942 Copy Product Info
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TMLZ-G46 is a novel, orally active ZNF207 inhibitor developed to target the ZNF207 protein, which is highly expressed in gliomas. It significantly inhibits glioma cell proliferation, migration, and tumor stemness. In animal models, TMLZ-G46 has demonstrated good blood-brain barrier permeability and anti-glioblastoma activity.
TMLZ-G46
Cas No. 3116767-83-7
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| Description | TMLZ-G46 is a novel, orally active ZNF207 inhibitor developed to target the ZNF207 protein, which is highly expressed in gliomas. It significantly inhibits glioma cell proliferation, migration, and tumor stemness. In animal models, TMLZ-G46 has demonstrated good blood-brain barrier permeability and anti-glioblastoma activity. |
| In vitro | TMLZ-G46 (10 μM; 3 h) binds to ZNF207 in LN229 and U251MG glioma cells, significantly enhancing the thermal stability of this protein [1]. TMLZ-G46 (72 h) potently inhibits the proliferation of ZNF207-overexpressing glioma cell lines (LN229, U251MG, HS683, T98G), with IC50 values below 3 μM, while its activity is reduced in ZNF207-low-expressing cell lines (U87MG, U118MG, U138MG)[1]. TMLZ-G46 (0.25–4 μM; 14 days) potently attenuates the clonogenic capacity of LN229 and U251MG glioma cells, with significant inhibition observed at concentrations as low as 0.25 μM [1]. TMLZ-G46 (10 days) selectively inhibits the self-renewal of glioma stem cell-like cells in LN229 and U251MG cells, with an IC50 value in the sub-micromolar range [1]. TMLZ-G46 (0.5–4 μM; 24 h) dose-dependently inhibits SOX2 expression in LN229 and U251MG glioma cells, providing evidence for its suppression of stem cell properties [1]. TMLZ-G46 (0–8 μM; 24–48 h) dose-dependently inhibits the migration and invasion capabilities of LN229 and U251MG glioma cells [1]. TMLZ-G46 (1–5 μM; 24 h) induces G0/G1 cell cycle arrest and apoptosis in LN229 and U251MG glioma cells [1]. |
| Molecular Weight | 575.74 |
| Formula | C37H41N3O3 |
| Cas No. | 3116767-83-7 |
| Smiles | N#CC(C(=O)NCCC1CCN(CC2=CC=C(OCC3CCCCC3)C=C2)CC1)=C4C=5C=CC=CC5OC=6C=CC=CC64 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: TMLZ-G46 in vitro | TMLZ-G46 formula | TMLZ-G46 molecular weight
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