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FAPI-46

Name: FAPI-46
Brand: TargetMol
SKU: T39922
Rating: 4.5 (1 reviews)

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Catalog No. T39922Cas No. 2374782-04-2

Alias FAPI46

FAPI-46 is a radiotracer for fibroblast activation protein (FAP), belonging to the class of FAP inhibitors (iFAP), and can be conjugated with labels such as 68Ga or 177Lu to serve as a tracer for FAP tumours in positron emission tomography (PET).

FAPI-46

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Catalog No. T39922Alias FAPI46Cas No. 2374782-04-2

Pack Size	Price	Availability	Quantity
5 mg	$747	Backorder
10 mg	$1,360	Backorder

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	FAPI-46 is a radiotracer for fibroblast activation protein (FAP), belonging to the class of FAP inhibitors (iFAP), and can be conjugated with labels such as 68Ga or 177Lu to serve as a tracer for FAP tumours in positron emission tomography (PET).
In vitro	FAPI-46 (1-24 h) was shown to strongly bind to human FAP in HT-1080 cells expressing human FAP. [1]
In vivo	FAPI-46 (intravenous injection) can show improved uptake ratios in tumors versus liver, kidneys, and brain, thereby enhancing image contrast in PET imaging [1] .
Synonyms	FAPI46

Chemical Properties

Molecular Weight	885.96
Formula	C₄₁H₅₇F₂N₁₁O₉
Cas No.	2374782-04-2
Smiles	C(NCC(=O)N1[C@H](C#N)CC(F)(F)C1)(=O)C=2C3=C(C=CC(N(CCCN4CCN(C(CN5CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC5)=O)CC4)C)=C3)N=CC2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 80 mg/mL (90.3 mM), Sonication is recommended.

DMSO: 80 mg/mL (90.3 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.1287 mL	5.6436 mL	11.2872 mL	56.4360 mL
5 mM	0.2257 mL	1.1287 mL	2.2574 mL	11.2872 mL
10 mM	0.1129 mL	0.5644 mL	1.1287 mL	5.6436 mL
20 mM	0.0564 mL	0.2822 mL	0.5644 mL	2.8218 mL
50 mM	0.0226 mL	0.1129 mL	0.2257 mL	1.1287 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

FAPI-46FAPI 46