MethADP

Name: MethADP
Brand: TargetMol
SKU: T12008
Price: 198 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T12008Cas No. 3768-14-7

Alias Adenosine 5'-(α,β-methylene)diphosphate

MethADP (Adenosine 5'-(α,β-methylene)diphosphate) is a specific CD73 inhibitor that inhibits the enzyme ecto-5′-nucleotidase (ecto), which has been used in the study of neurological and cardiovascular diseases.

MethADP

🥰Excellent

Catalog No. T12008Alias Adenosine 5'-(α,β-methylene)diphosphateCas No. 3768-14-7

Pack Size	Price	Availability
1 mg	$198	In Stock
2 mg	$293	In Stock
5 mg	$496	In Stock
10 mg	$693	In Stock
25 mg	$1,070	In Stock
50 mg	$1,450	In Stock
100 mg	$1,960	In Stock

Add to Cart

Add to Quotation

Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

Questions

Batch Information

Select Batch

Purity:>99.99%

Resource Download

COA HNMR LCMS PNMR

Product Introduction

Bioactivity

Description	MethADP (Adenosine 5'-(α,β-methylene)diphosphate) is a specific CD73 inhibitor that inhibits the enzyme ecto-5′-nucleotidase (ecto), which has been used in the study of neurological and cardiovascular diseases.
In vitro	MethADP (AMP-CP: 20 μM) significantly inhibits adenosine formation (0.96±0.96 μM) compared to untreated controls (9.6±1.5 μM) in A498 and RT4 cells, with complete inhibition observed at 100 μM.
Synonyms	Adenosine 5'-(α,β-methylene)diphosphate

Chemical Properties

Molecular Weight	425.23
Formula	C₁₁H₁₇N₅O₉P₂
Cas No.	3768-14-7
Smiles	O[C@H]1[C@H](N2C=3C(N=C2)=C(N)N=CN3)O[C@H](COP(CP(=O)(O)O)(=O)O)[C@H]1O
Relative Density.	1.31g/cm3
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc