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Vipivotide tetraxetan

Name: Vipivotide tetraxetan
Brand: TargetMol
SKU: T12573
Price: 193 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12573Cas No. 1702967-37-0

Alias PSMA-617

Vipivotide tetraxetan (PSMA-617) is a highly potent inhibitor of prostate-specific membrane antigen (PSMA) with a Ki of 0.37 nM.

Vipivotide tetraxetan

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Purity: 99.9%

Catalog No. T12573Alias PSMA-617Cas No. 1702967-37-0

Vipivotide tetraxetan (PSMA-617) is a highly potent inhibitor of prostate-specific membrane antigen (PSMA) with a Ki of 0.37 nM.

Pack Size	Price	Availability
1 mg	$193	In Stock
2 mg	$287	In Stock
5 mg	$483	In Stock
10 mg	$691	In Stock
25 mg	$1,080	In Stock
50 mg	$1,490	In Stock
100 mg	$1,960	In Stock
1 mL x 10 mM (in DMSO)	$1,190	In Stock

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Purity:99.9%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Vipivotide tetraxetan (PSMA-617) is a highly potent inhibitor of prostate-specific membrane antigen (PSMA) with a Ki of 0.37 nM.
Targets&IC50	PSMA:0.37 nM (Ki), LNCaP cells:2.34 - 2.94 nM (Ki)
In vitro	The chemically modified PSMA inhibitor PSMA-617 demonstrated high radiolytic stability for at least 72 h. A high inhibition potency (equilibrium dissociation constant [K(i)] = 2.34 2.94 nM on LNCaP; K(i) = 0.37 0.21 nM enzymatically determined) and highly efficient internalization into LNCaP cells were demonstrated.
In vivo	The small-animal PET measurements showed high tumor-to-background contrasts as early as 1 h after injection of Vipivotide tetraxetan.Organ distribution revealed specific uptake in LNCaP tumors and in the kidneys 1 h after injection of Vipivotide tetraxetan[1].
Synonyms	PSMA-617

Chemical Properties

Molecular Weight	1042.14
Formula	C₄₉H₇₁N₉O₁₆
Cas No.	1702967-37-0
Smiles	OC(=O)CC[C@H](NC(=O)N[C@@H](CCCCNC(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1CC[C@H](CNC(=O)CN2CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC2)CC1)C(O)=O)C(O)=O
Relative Density.	1.322 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (95.96 mM), Sonication is recommended.

H2O: 100 mg/mL (95.96 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (3.84 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	0.9596 mL	4.7978 mL	9.5956 mL	47.9782 mL
5 mM	0.1919 mL	0.9596 mL	1.9191 mL	9.5956 mL
10 mM	0.0960 mL	0.4798 mL	0.9596 mL	4.7978 mL
20 mM	0.0480 mL	0.2399 mL	0.4798 mL	2.3989 mL
50 mM	0.0192 mL	0.0960 mL	0.1919 mL	0.9596 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc