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TS-002266

🥰Excellent
Catalog No. T200755Cas No. 2702325-64-0
Alias TS002266

TS-0022666 is a selective TUT4/7 inhibitor exhibiting antiproliferative and anti-leukaemic activity in vivo and in vitro. It enhances THP-1 cell sensitivity to BCL-2 inhibition, reduces uridylation, and may be used to study cancers with FOCAD deficiency.

TS-002266

TS-002266

🥰Excellent
Purity: 98.18%
Catalog No. T200755Alias TS002266Cas No. 2702325-64-0
TS-0022666 is a selective TUT4/7 inhibitor exhibiting antiproliferative and anti-leukaemic activity in vivo and in vitro. It enhances THP-1 cell sensitivity to BCL-2 inhibition, reduces uridylation, and may be used to study cancers with FOCAD deficiency.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$339-In Stock
5 mg$793-In Stock
10 mg$1,280-In Stock
25 mg$2,380-In Stock
50 mg$3,730-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:98.18%
ee:100%
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Product Introduction

Bioactivity
Description
TS-0022666 is a selective TUT4/7 inhibitor exhibiting antiproliferative and anti-leukaemic activity in vivo and in vitro. It enhances THP-1 cell sensitivity to BCL-2 inhibition, reduces uridylation, and may be used to study cancers with FOCAD deficiency.
SynonymsTS002266
Chemical Properties
Molecular Weight639.53
FormulaC31H32Cl2N6O5
Cas No.2702325-64-0
SmilesO=C1C=2C(N(C=C1C(O)=O)C=3C=CC(=NC3)N4CC(N(C)C)C4)=CC(=C(Cl)C2)N5[C@@H](COC6=C(Cl)C(OC)=CC=N6)CCC5
Relative Density.no data available
ColorYellow
AppearanceSolid
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (125.09 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (5.16 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.5636 mL7.8182 mL15.6365 mL78.1824 mL
5 mM0.3127 mL1.5636 mL3.1273 mL15.6365 mL
10 mM0.1564 mL0.7818 mL1.5636 mL7.8182 mL
20 mM0.0782 mL0.3909 mL0.7818 mL3.9091 mL
50 mM0.0313 mL0.1564 mL0.3127 mL1.5636 mL
100 mM0.0156 mL0.0782 mL0.1564 mL0.7818 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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